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10.1213/XAA.0000000000000140

http://scihub22266oqcxt.onion/10.1213/XAA.0000000000000140
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suck abstract from ncbi


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pmid26035220      A+A+Case+Rep 2015 ; 4 (11): 148-50
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  • Emergence delirium with transient associative agnosia and expressive aphasia reversed by flumazenil in a pediatric patient #MMPMID26035220
  • Drobish JK; Kelz MB; DiPuppo PM; Cook-Sather SD
  • A A Case Rep 2015[Jun]; 4 (11): 148-50 PMID26035220show ga
  • Multiple factors may contribute to the development of emergence delirium in a child. We present the case of a healthy 12-year-old girl who received preoperative midazolam with the desired anxiolytic effect, underwent a brief general anesthetic, and then exhibited postoperative delirium, consisting of a transient associative agnosia and expressive aphasia. Administration of flumazenil led to immediate and lasting resolution of her symptoms. We hypothesize that gamma-aminobutyric acid type A receptor-mediated effects, most likely related to an atypical offset of midazolam, are an important subset of emergence delirium that is amenable to pharmacologic therapy with flumazenil.
  • |Adjuvants, Anesthesia/*adverse effects[MESH]
  • |Agnosia/*chemically induced[MESH]
  • |Anesthesia, General[MESH]
  • |Aphasia, Broca/*chemically induced[MESH]
  • |Child[MESH]
  • |Delirium/*chemically induced/drug therapy[MESH]
  • |Female[MESH]
  • |Flumazenil/*therapeutic use[MESH]
  • |GABA-A Receptor Antagonists/*therapeutic use[MESH]
  • |Humans[MESH]
  • |Midazolam/*adverse effects[MESH]


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