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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 A+A+Case+Rep 2015 ; 4 (11): 148-50 Nephropedia Template TP
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Emergence delirium with transient associative agnosia and expressive aphasia reversed by flumazenil in a pediatric patient #MMPMID26035220
Drobish JK; Kelz MB; DiPuppo PM; Cook-Sather SD
A A Case Rep 2015[Jun]; 4 (11): 148-50 PMID26035220show ga
Multiple factors may contribute to the development of emergence delirium in a child. We present the case of a healthy 12-year-old girl who received preoperative midazolam with the desired anxiolytic effect, underwent a brief general anesthetic, and then exhibited postoperative delirium, consisting of a transient associative agnosia and expressive aphasia. Administration of flumazenil led to immediate and lasting resolution of her symptoms. We hypothesize that gamma-aminobutyric acid type A receptor-mediated effects, most likely related to an atypical offset of midazolam, are an important subset of emergence delirium that is amenable to pharmacologic therapy with flumazenil.