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10.1007/978-3-319-16009-2_8 http://scihub22266oqcxt.onion/10.1007/978-3-319-16009-2_8 26002737!5177021!26002737     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26002737&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Adv+Exp+Med+Biol 2015 ; 851 (?): 209-28 Nephropedia Template TP {{tp|p=26002737|t=2015. Use of chemical auxiliaries to control p450 enzymes for predictable oxidations at unactivated C-h bonds of substrates |pdf=|usr=}}{{26002737}} gab.com Text Use of chemical auxiliaries to control p450 enzymes for predictable oxidations at unactivated C-h bonds of substrates JO: Adv Exp Med Biol http://www.kidney.de/pget.php?&tw=1&pmid=26002737 #FOAvip Cytochrome P450 enzymes (P450s) have the ability to oxidize unactivated C-H bonds of substrates with remarkable regio- and stereoselectivity. Comparable selectivity for chemical oxidizing agents is typically difficult to achieve. Hence, there is an interest in exploiting P450s as potential biocatalysts. Despite their impressive attributes, the current use of P450s as biocatalysts is limited. While bacterial P450 enzymes typically show higher activity, they tend to be highly selective for one or a few substrates. On the other hand, mammalian P450s, especially the drug-metabolizing enzymes, display astonishing substrate promiscuity. However, product prediction continues to be challenging. This review discusses the use of small molecules for controlling P450 substrate specificity and product selectivity. The focus will be on two approaches in the area: (1) the use of decoy molecules, and (2) the application of substrate engineering to control oxidation by the enzyme. Twit Text FOAVip Use of chemical auxiliaries to control p450 enzymes for predictable oxidations at unactivated C-h bonds of substrates ????Adv Exp Med Biol http://www.kidney.de/pget.php?&tw=1&pmid=26002737 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26002737 #FOAvip English Wikipedia <ref>{{Cite pmid|26002737}}</ref> Use of chemical auxiliaries to control p450 enzymes for predictable oxidations at unactivated C-h bonds of substrates #MMPMID26002737 Auclair K; Polic V Adv Exp Med Biol 2015[]; 851 (?): 209-28 PMID26002737show ga Cytochrome P450 enzymes (P450s) have the ability to oxidize unactivated C-H bonds of substrates with remarkable regio- and stereoselectivity. Comparable selectivity for chemical oxidizing agents is typically difficult to achieve. Hence, there is an interest in exploiting P450s as potential biocatalysts. Despite their impressive attributes, the current use of P450s as biocatalysts is limited. While bacterial P450 enzymes typically show higher activity, they tend to be highly selective for one or a few substrates. On the other hand, mammalian P450s, especially the drug-metabolizing enzymes, display astonishing substrate promiscuity. However, product prediction continues to be challenging. This review discusses the use of small molecules for controlling P450 substrate specificity and product selectivity. The focus will be on two approaches in the area: (1) the use of decoy molecules, and (2) the application of substrate engineering to control oxidation by the enzyme. |Animals[MESH] |Bacteria/enzymology[MESH] |Bacterial Proteins/chemistry/metabolism[MESH] |Catalysis[MESH] |Cytochrome P-450 Enzyme System/*chemistry/*metabolism[MESH] |Humans[MESH] |Oxidation-Reduction[MESH]Use of chemical auxiliaries to control p450 enzymes for predictable ox(epmc).pdf DeepDyve Pubget Overpricing