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10.1684/mrh.2015.0379

http://scihub22266oqcxt.onion/10.1684/mrh.2015.0379
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25967879!ä!25967879

suck abstract from ncbi


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pmid25967879      Magnes+Res 2015 ; 28 (1): 1-13
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  • The relationship between repolarization parameters and serum electrolyte levels in patients with J wave syndromes #MMPMID25967879
  • Sato N; Sasaki R; Imahashi M; Ito E; Saito K; Kubota H; Talib AK; Sakamoto N; Akasaka K; Saijo Y; Kawamura Y; Fujii S; Hasebe N
  • Magnes Res 2015[Jan]; 28 (1): 1-13 PMID25967879show ga
  • BACKGROUND: Intravenous administration of magnesium (Mg(2+)) is effective for polymorphic ventricular tachycardia via homogenization of transmural ventricular repolarization. Mg(2+) likely plays some role in the heterogeneity of repolarization in J wave syndromes. OBJECTIVE: To investigate the relationship between the repolarization parameters and serum Mg(2+), potassium (K(+)), and calcium (Ca(2+)) levels in J wave syndromes. METHODS: Thirteen J-wave syndrome patients (Brugada and early repolarization [ER] syndromes), with documented episodes of ventricular fibrillation (VF), and 13 ER pattern (ERP) or Brugada type ECG patients were enrolled (25 males, mean age 48 +/- 15 years). The 12-lead ECG-derived parameters including the QT, QT dispersion (QTd), Tpeak-Tend (Tp-e) interval, Tp-e dispersion (Tp-ed), Tp-e/QT ratio, and activation recovery interval (ARI) dispersion were calculated; the correlations between these parameters and electrolytes including Mg(2+), K(+), and Ca(2+) were analyzed. RESULTS: Although there was no association between serum K(+) or Ca(2+) and QTd, there was a strong negative correlation between serum Mg(2+) and QTd in J wave syndrome patients with a history of VF (r = -0.715, p = 0.006). Also, there was a tendency for a negative correlation between Mg(2+) and Tp-ed or ARI dispersion in J wave syndrome patients with a history of VF (r = -0.513, p = 0.072 and r = -0.53, p = 0.063, respectively). On the other hand, in 13 patients with a Brugada type ECG or ERP, no correlation was observed between serum Mg(2+) and the QTd, Tp-ed or ARI dispersion. CONCLUSION: Serum Mg(2+) may play an important role in the cardiac repolarization process in J wave syndromes.
  • |Adult[MESH]
  • |Arrhythmias, Cardiac/*blood/*physiopathology[MESH]
  • |Brugada Syndrome/blood/physiopathology[MESH]
  • |Calcium/blood[MESH]
  • |Electrocardiography[MESH]
  • |Electrolytes/*blood[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Magnesium/*blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Potassium/blood[MESH]
  • |Syndrome[MESH]
  • |Tachycardia, Ventricular/*blood/*physiopathology[MESH]


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