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10.1007/s00109-015-1291-1 http://scihub22266oqcxt.onion/10.1007/s00109-015-1291-1 25940317!ä!25940317 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Med+(Berl) 2015 ; 93 (10): 1131-43 Nephropedia Template TP {{tp|p=25940317|t=2015. DcR3 suppresses influenza virus-induced macrophage activation and attenuates pulmonary inflammation and lethality |pdf=|usr=}}{{25940317}} gab.com Text DcR3 suppresses influenza virus-induced macrophage activation and attenuates pulmonary inflammation and lethality JO: J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=25940317 #FOAvip Influenza A virus (IAV) infects macrophages and stimulates innate immunity receptors and sensors to produce proinflammatory cytokines and chemokines, which are responsible for IAV-induced pulmonary inflammation and injury. Decoy receptor 3 (DcR3) is a soluble protein belonging to the tumor necrosis factor receptor superfamily (TNFRSF), and is able to skew macrophage differentiation into an M2 phenotype. We demonstrated that DcR3 attenuated IAV-induced secretion of proinflammatory cytokines and chemokine from macrophages, and mitigated pulmonary infiltration and reduce lethality. Proteome-wide phosphoproteomic mapping revealed that DcR3 not only activated STK10, a negative regulator of cell migration, but also inactivated PKC-alpha, which are crucial for the activation of ERK and JNK in human macrophages. Furthermore, less pulmonary infiltration with lower levels of proinflammatory cytokines and chemokine in bronchoalveolar lavage fluid (BALF) were observed in DcR3-transgenic mice. Moreover, recombinant DcR3.Fc and heparan sulfate proteoglycan binding domain of DcR3.Fc (HBD.Fc) fusion proteins attenuated weight loss and protected mice from IAV-induced lethality. Thus, DcR3-mediated protection is not only via suppression of proinflammatory cytokine and chemokine release, but also via activation of STK10 to inhibit cell infiltration. DcR3 fusion proteins may become therapeutic agents to protect host from IAV-induced lethality in the future. KEY MESSAGE: * DcR3 suppresses IAV-induced cytokine secretion.* DcR3 inhibits IAV-induced JNK and ERK activation in human macrophages.* DcR3 downregulates TLR3 and 7 expressions in human macrophages.* DcR3 protects mice from IAV-induced lethality. Twit Text FOAVip DcR3 suppresses influenza virus-induced macrophage activation and attenuates pulmonary inflammation and lethality ????J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=25940317 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25940317 #FOAvip English Wikipedia <ref>{{Cite pmid|25940317}}</ref> DcR3 suppresses influenza virus-induced macrophage activation and attenuates pulmonary inflammation and lethality #MMPMID25940317 Huang MT; Chen ST; Wu HY; Chen YJ; Chou TY; Hsieh SL J Mol Med (Berl) 2015[Oct]; 93 (10): 1131-43 PMID25940317show ga Influenza A virus (IAV) infects macrophages and stimulates innate immunity receptors and sensors to produce proinflammatory cytokines and chemokines, which are responsible for IAV-induced pulmonary inflammation and injury. Decoy receptor 3 (DcR3) is a soluble protein belonging to the tumor necrosis factor receptor superfamily (TNFRSF), and is able to skew macrophage differentiation into an M2 phenotype. We demonstrated that DcR3 attenuated IAV-induced secretion of proinflammatory cytokines and chemokine from macrophages, and mitigated pulmonary infiltration and reduce lethality. Proteome-wide phosphoproteomic mapping revealed that DcR3 not only activated STK10, a negative regulator of cell migration, but also inactivated PKC-alpha, which are crucial for the activation of ERK and JNK in human macrophages. Furthermore, less pulmonary infiltration with lower levels of proinflammatory cytokines and chemokine in bronchoalveolar lavage fluid (BALF) were observed in DcR3-transgenic mice. Moreover, recombinant DcR3.Fc and heparan sulfate proteoglycan binding domain of DcR3.Fc (HBD.Fc) fusion proteins attenuated weight loss and protected mice from IAV-induced lethality. Thus, DcR3-mediated protection is not only via suppression of proinflammatory cytokine and chemokine release, but also via activation of STK10 to inhibit cell infiltration. DcR3 fusion proteins may become therapeutic agents to protect host from IAV-induced lethality in the future. KEY MESSAGE: * DcR3 suppresses IAV-induced cytokine secretion.* DcR3 inhibits IAV-induced JNK and ERK activation in human macrophages.* DcR3 downregulates TLR3 and 7 expressions in human macrophages.* DcR3 protects mice from IAV-induced lethality. |*Influenza A virus[MESH] |Animals[MESH] |Bronchoalveolar Lavage Fluid/cytology/immunology[MESH] |Cytokines/immunology[MESH] |Heparan Sulfate Proteoglycans/genetics[MESH] |Humans[MESH] |Immunoglobulin G/pharmacology[MESH] |Lung/virology[MESH] |Macrophage Activation/*immunology[MESH] |Mice, Inbred C57BL[MESH] |Mice, Transgenic[MESH] |Mitogen-Activated Protein Kinases/*immunology[MESH] |Orthomyxoviridae Infections/*immunology[MESH] |Pneumonia/*immunology[MESH] |Protein Structure, Tertiary[MESH] |Receptors, Tumor Necrosis Factor, Member 6b/genetics/*immunology[MESH] |Recombinant Fusion Proteins/pharmacology[MESH]DcR3 suppresses influenza virus-induced macrophage activation and atte(epmc).pdf DeepDyve Pubget Overpricing