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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Neuroimmunol 2015 ; 282 (ä): 97-103 Nephropedia Template TP
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Immune cell expression of GABAA receptors and the effects of diazepam on influenza infection #MMPMID25903735
Sanders RD; Grover V; Goulding J; Godlee A; Gurney S; Snelgrove R; Ma D; Singh S; Maze M; Hussell T
J Neuroimmunol 2015[May]; 282 (ä): 97-103 PMID25903735show ga
Benzodiazepines increase vulnerability to infection through alpha1 subunit dependent Upsilon-amino-butyric-type-A (GABAA) signalling. Immune cell expression of GABAA receptors and the effect of diazepam on influenza infection was investigated. In patients with pneumonia, alpha1 GABAA subunits were expressed on alveolar macrophages and blood monocytes. In mice, influenza induced dynamic changes in immune cell GABAA subunit expression: alpha1 subunits decreased on alveolar macrophage, but increased on monocytes, CD4+ and CD8+ T cells. Following influenza viral infection, diazepam delayed weight loss on day 3 but later increased weight loss. Viral load was unaffected but increased bacterial superinfection was noted on day 10.