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10.1021/ml5005156 http://scihub22266oqcxt.onion/10.1021/ml5005156 25893048/?report=reader!4394347!25893048     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2015 ; 6 (4): 450-4 Nephropedia Template TP {{tp|p=25893048|t=2015. Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development |pdf=|usr=}}{{25893048}} gab.com Text Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=25893048 #FOAvip The preclinical characterization of novel phenyl(piperazin-1-yl)methanones that are histamine H3 receptor antagonists is described. The compounds described are high affinity histamine H3 antagonists. Optimization of the physical properties of these histamine H3 antagonists led to the discovery of several promising lead compounds, and extensive preclinical profiling aided in the identification of compounds with optimal duration of action for wake promoting activity. This led to the discovery of two development candidates for Phase I and Phase II clinical trials. Twit Text FOAVip Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=25893048 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25893048 #FOAvip English Wikipedia <ref>{{Cite pmid|25893048}}</ref> Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development #MMPMID25893048 Letavic MA; Aluisio L; Apodaca R; Bajpai M; Barbier AJ; Bonneville A; Bonaventure P; Carruthers NI; Dugovic C; Fraser IC; Kramer ML; Lord B; Lovenberg TW; Li LY; Ly KS; Mcallister H; Mani NS; Morton KL; Ndifor A; Nepomuceno SD; Pandit CR; Sands SB; Shah CR; Shelton JE; Snook SS; Swanson DM; Xiao W ACS Med Chem Lett 2015[Apr]; 6 (4): 450-4 PMID25893048show ga The preclinical characterization of novel phenyl(piperazin-1-yl)methanones that are histamine H3 receptor antagonists is described. The compounds described are high affinity histamine H3 antagonists. Optimization of the physical properties of these histamine H3 antagonists led to the discovery of several promising lead compounds, and extensive preclinical profiling aided in the identification of compounds with optimal duration of action for wake promoting activity. This led to the discovery of two development candidates for Phase I and Phase II clinical trials. äNovel benzamide-based histamine h3 receptor antagonists: the identific(epmc).pdf DeepDyve Pubget Overpricing