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10.1111/acps.12424 http://scihub22266oqcxt.onion/10.1111/acps.12424 25891484!4942271!25891484     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Psychiatr+Scand 2015 ; 132 (5): 379-88 Nephropedia Template TP {{tp|p=25891484|t=2015. Light therapy and serotonin transporter binding in the anterior cingulate and prefrontal cortex |pdf=|usr=}}{{25891484}} gab.com Text Light therapy and serotonin transporter binding in the anterior cingulate and prefrontal cortex JO: Acta Psychiatr Scand http://www.kidney.de/pget.php?&tw=1&pmid=25891484 #FOAvip OBJECTIVE: To investigate the effects of light therapy on serotonin transporter binding (5-HTT BPND ), an index of 5-HTT levels, in the anterior cingulate and prefrontal cortices (ACC and PFC) of healthy individuals during the fall and winter. Twenty-five per cent of healthy individuals experience seasonal mood changes that affect functioning. 5-HTT BPND has been found to be higher across multiple brain regions in the fall and winter relative to spring and summer, and elevated 5-HTT BPND may lead to extracellular serotonin loss and low mood. We hypothesized that, during the fall and winter, light therapy would reduce 5-HTT BPND in the ACC and PFC, which sample brain regions involved in mood regulation. METHOD: In a single-blind, placebo-controlled, counterbalanced, crossover design, [(11) C]DASB positron emission tomography was used measure 5-HTT BPND following light therapy and placebo conditions during fall and winter. RESULTS: In winter, light therapy significantly decreased 5-HTT BPND by 12% in the ACC relative to placebo (F1,9 = 18.04, P = 0.002). In the fall, no significant change in 5-HTT BPND was found in any region across conditions. CONCLUSION: These results identify, for the first time, a central biomarker associated with the intervention of light therapy in humans which may be applied to further develop this treatment for prevention of seasonal depression. Twit Text FOAVip Light therapy and serotonin transporter binding in the anterior cingulate and prefrontal cortex ????Acta Psychiatr Scand http://www.kidney.de/pget.php?&tw=1&pmid=25891484 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25891484 #FOAvip English Wikipedia <ref>{{Cite pmid|25891484}}</ref> Light therapy and serotonin transporter binding in the anterior cingulate and prefrontal cortex #MMPMID25891484 Harrison SJ; Tyrer AE; Levitan RD; Xu X; Houle S; Wilson AA; Nobrega JN; Rusjan PM; Meyer JH Acta Psychiatr Scand 2015[Nov]; 132 (5): 379-88 PMID25891484show ga OBJECTIVE: To investigate the effects of light therapy on serotonin transporter binding (5-HTT BPND ), an index of 5-HTT levels, in the anterior cingulate and prefrontal cortices (ACC and PFC) of healthy individuals during the fall and winter. Twenty-five per cent of healthy individuals experience seasonal mood changes that affect functioning. 5-HTT BPND has been found to be higher across multiple brain regions in the fall and winter relative to spring and summer, and elevated 5-HTT BPND may lead to extracellular serotonin loss and low mood. We hypothesized that, during the fall and winter, light therapy would reduce 5-HTT BPND in the ACC and PFC, which sample brain regions involved in mood regulation. METHOD: In a single-blind, placebo-controlled, counterbalanced, crossover design, [(11) C]DASB positron emission tomography was used measure 5-HTT BPND following light therapy and placebo conditions during fall and winter. RESULTS: In winter, light therapy significantly decreased 5-HTT BPND by 12% in the ACC relative to placebo (F1,9 = 18.04, P = 0.002). In the fall, no significant change in 5-HTT BPND was found in any region across conditions. CONCLUSION: These results identify, for the first time, a central biomarker associated with the intervention of light therapy in humans which may be applied to further develop this treatment for prevention of seasonal depression. |*Seasons[MESH] |Adult[MESH] |Biomarkers/metabolism[MESH] |Cross-Over Studies[MESH] |Female[MESH] |Gyrus Cinguli/*metabolism[MESH] |Humans[MESH] |Male[MESH] |Phototherapy/instrumentation/*methods[MESH] |Positron-Emission Tomography/*methods[MESH] |Prefrontal Cortex/*metabolism[MESH] |Protein Binding[MESH] |Serotonin Plasma Membrane Transport Proteins/*metabolism[MESH] |Single-Blind Method[MESH]Light therapy and serotonin transporter binding in the anterior cingul(epmc).pdf DeepDyve Pubget Overpricing