Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1097/QAD.0000000000000654 http://scihub22266oqcxt.onion/10.1097/QAD.0000000000000654 25870985!4478137!25870985     free     free     free       AIDS 2015 ; 29 (11): 1325-33 Nephropedia Template TP {{tp|p=25870985|t=2015. Association of HIV, hepatitis C virus and liver fibrosis severity with interleukin-6 and C-reactive protein levels |pdf=|usr=}}{{25870985}} gab.com Text Association of HIV, hepatitis C virus and liver fibrosis severity with interleukin-6 and C-reactive protein levels JO: AIDS http://www.kidney.de/pget.php?&tw=1&pmid=25870985 #FOAvip BACKGROUND: Hepatitis C virus (HCV) infection is associated with chronic inflammation; yet studies show greater interleukin (IL)-6, but lower C-reactive protein (CRP) levels. We determined whether liver fibrosis severity and HCV replication affect the ability of IL-6 to stimulate the production of CRP from the liver. METHODS: We used multivariable generalized linear regression to examine the association of HIV, HCV and transient elastography-measured liver stiffness with IL-6 and CRP in participants (164 HIV-monoinfected; 10 HCV-monoinfected; 73 HIV/HCV-coinfected; 59 neither infection) of the Women's Interagency HIV Study. Significant fibrosis was defined as liver stiffness greater than 7.1 kPa. RESULTS: IL-6 was positively correlated with CRP levels in all women, but CRP levels were lower in HCV-infected women (with and without HIV infection) at all levels of IL-6. HCV-infected women with fibrosis had nearly 2.7-fold higher IL-6 levels compared to controls [95% confidence interval (CI 146%, 447%]; HCV-infected women without fibrosis had IL-6 levels that were similar to controls. By contrast, CRP was 28% lower in HCV-infected women with fibrosis (95% CI -55%, 15%) and 47% lower in HCV-infected women without fibrosis (95% CI -68%, -12%). Among the HCV-infected women, higher HCV-RNA levels were associated with 9% lower CRP levels per doubling (95% CI -18%, 0%). CONCLUSION: Liver fibrosis severity is associated with greater IL-6 levels, but the stimulatory effect of IL-6 on CRP appears to be blunted by HCV replication rather than by liver fibrosis severity. Investigation of the potential CRP rebound after HCV-RNA eradication and persistent liver fibrosis on organ injury is needed. Twit Text FOAVip Association of HIV, hepatitis C virus and liver fibrosis severity with interleukin-6 and C-reactive protein levels ????AIDS http://www.kidney.de/pget.php?&tw=1&pmid=25870985 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25870985 #FOAvip English Wikipedia <ref>{{Cite pmid|25870985}}</ref> Association of HIV, hepatitis C virus and liver fibrosis severity with interleukin-6 and C-reactive protein levels #MMPMID25870985 Shah S; Ma Y; Scherzer R; Huhn G; French AL; Plankey M; Peters MG; Grunfeld C; Tien PC AIDS 2015[Jul]; 29 (11): 1325-33 PMID25870985show ga BACKGROUND: Hepatitis C virus (HCV) infection is associated with chronic inflammation; yet studies show greater interleukin (IL)-6, but lower C-reactive protein (CRP) levels. We determined whether liver fibrosis severity and HCV replication affect the ability of IL-6 to stimulate the production of CRP from the liver. METHODS: We used multivariable generalized linear regression to examine the association of HIV, HCV and transient elastography-measured liver stiffness with IL-6 and CRP in participants (164 HIV-monoinfected; 10 HCV-monoinfected; 73 HIV/HCV-coinfected; 59 neither infection) of the Women's Interagency HIV Study. Significant fibrosis was defined as liver stiffness greater than 7.1 kPa. RESULTS: IL-6 was positively correlated with CRP levels in all women, but CRP levels were lower in HCV-infected women (with and without HIV infection) at all levels of IL-6. HCV-infected women with fibrosis had nearly 2.7-fold higher IL-6 levels compared to controls [95% confidence interval (CI 146%, 447%]; HCV-infected women without fibrosis had IL-6 levels that were similar to controls. By contrast, CRP was 28% lower in HCV-infected women with fibrosis (95% CI -55%, 15%) and 47% lower in HCV-infected women without fibrosis (95% CI -68%, -12%). Among the HCV-infected women, higher HCV-RNA levels were associated with 9% lower CRP levels per doubling (95% CI -18%, 0%). CONCLUSION: Liver fibrosis severity is associated with greater IL-6 levels, but the stimulatory effect of IL-6 on CRP appears to be blunted by HCV replication rather than by liver fibrosis severity. Investigation of the potential CRP rebound after HCV-RNA eradication and persistent liver fibrosis on organ injury is needed. |Adult[MESH] |Coinfection[MESH] |Elasticity Imaging Techniques[MESH] |Female[MESH] |HIV Infections/*blood/complications[MESH] |Hepacivirus/*genetics[MESH] |Hepatitis C, Chronic/*blood/complications[MESH] |Humans[MESH] |Interleukin-6/*blood[MESH] |Linear Models[MESH] |Liver Cirrhosis/*blood[MESH] |Middle Aged[MESH] |Multivariate Analysis[MESH] |Prospective Studies[MESH] |Receptors, Immunologic/*blood[MESH]Association of HIV, hepatitis C virus and liver fibrosis severity with(epmc).pdf DeepDyve Pubget Overpricing