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10.1007/978-3-662-44605-8_16 http://scihub22266oqcxt.onion/10.1007/978-3-662-44605-8_16 25861786!ä!25861786 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Handb+Exp+Pharmacol 2015 ; 226 (ä): 291-314 Nephropedia Template TP {{tp|p=25861786|t=2015. Targeting Itch with Ligands Selective for kappa Opioid Receptors |pdf=|usr=}}{{25861786}} gab.com Text Targeting Itch with Ligands Selective for kappa Opioid Receptors JO: Handb Exp Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25861786 #FOAvip Several chemically diverse pruritogens, including bombesin, compound 48/80, norbinaltorphimine, and 5'-GNTI, cause rodents to scratch excessively in a stable, uniform manner and consequently provide convenient animal models of itch against which potential antipruritics may be evaluated, structure-activity relationships established, and the nature of spontaneous, repetitive behavior itself analyzed. Decreasing the number of scratching bouts in these apparently simple models has been the requisite first step in the progress of kappa opioid agonists such as nalbuphine, asimadoline, and CR845 toward clinical testing as antipruritics. Nalfurafine is the prime example of a kappa agonist spanning the developmental divide between scratching mice models and commercialization within 10 years. Patients undergoing hemodialysis and suffering from the itching associated with uremic pruritus, and potentially those inflicted with atopic dermatitis, are the beneficiaries. Twit Text FOAVip Targeting Itch with Ligands Selective for kappa Opioid Receptors ????Handb Exp Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25861786 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25861786 #FOAvip English Wikipedia <ref>{{Cite pmid|25861786}}</ref> Targeting Itch with Ligands Selective for kappa Opioid Receptors #MMPMID25861786 Cowan A; Kehner GB; Inan S Handb Exp Pharmacol 2015[]; 226 (ä): 291-314 PMID25861786show ga Several chemically diverse pruritogens, including bombesin, compound 48/80, norbinaltorphimine, and 5'-GNTI, cause rodents to scratch excessively in a stable, uniform manner and consequently provide convenient animal models of itch against which potential antipruritics may be evaluated, structure-activity relationships established, and the nature of spontaneous, repetitive behavior itself analyzed. Decreasing the number of scratching bouts in these apparently simple models has been the requisite first step in the progress of kappa opioid agonists such as nalbuphine, asimadoline, and CR845 toward clinical testing as antipruritics. Nalfurafine is the prime example of a kappa agonist spanning the developmental divide between scratching mice models and commercialization within 10 years. Patients undergoing hemodialysis and suffering from the itching associated with uremic pruritus, and potentially those inflicted with atopic dermatitis, are the beneficiaries. |Animals[MESH] |Dynorphins/pharmacology[MESH] |Guanidines/pharmacology[MESH] |Humans[MESH] |Ligands[MESH] |Mice[MESH] |Morphinans/pharmacology[MESH] |Naltrexone/analogs & derivatives/pharmacology[MESH] |Peptide Fragments/pharmacology[MESH] |Pruritus/*drug therapy[MESH] |Receptors, Opioid, kappa/*agonists[MESH] |Spiro Compounds/pharmacology[MESH]Targeting Itch with Ligands Selective for kappa Opioid Receptors (epmc).pdf DeepDyve Pubget Overpricing