Crystalloid glomerulopathy in monoclonal gammopathy of renal significance (MGRS) #MMPMID25852893
Vankalakunti M; Bonu R; Shetty S; Siddini V; Babu K; Ballal SH
Clin Kidney J 2014[Jun]; 7 (3): 296-8 PMID25852893show ga
We report a case of monoclonal gammopathy of renal significance in a 63-year-old man who presented with nephrotic-range proteinuria and renal insufficiency. The kidney biopsy showed a membranoproliferative glomerulonephritis pattern with extensive crystalloid deposits in the glomerular capillary endothelial cells and very few in the tubular epithelial cells. The immunoperoxidase staining showed kappa light chain restriction. Subsequently, the bone marrow showed 6% plasma cells which confirmed the diagnosis of monoclonal gammopathy of renal significance. He responded well to bortezomib treatment with resolution of the nephrotic syndrome and normalization of renal function after 7 months.