Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1126/science.aaa4268 http://scihub22266oqcxt.onion/10.1126/science.aaa4268 25766237!4376966!25766237     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2015 ; 347 (6227): 1260-5 Nephropedia Template TP {{tp|p=25766237|t=2015. Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis |pdf=|usr=}}{{25766237}} gab.com Text Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=25766237 #FOAvip Sepsis is a frequently fatal condition characterized by an uncontrolled and harmful host reaction to microbial infection. Despite the prevalence and severity of sepsis, we lack a fundamental grasp of its pathophysiology. Here we report that the cytokine interleukin-3 (IL-3) potentiates inflammation in sepsis. Using a mouse model of abdominal sepsis, we showed that innate response activator B cells produce IL-3, which induces myelopoiesis of Ly-6C(high) monocytes and neutrophils and fuels a cytokine storm. IL-3 deficiency protects mice against sepsis. In humans with sepsis, high plasma IL-3 levels are associated with high mortality even after adjusting for prognostic indicators. This study deepens our understanding of immune activation, identifies IL-3 as an orchestrator of emergency myelopoiesis, and reveals a new therapeutic target for treating sepsis. Twit Text FOAVip Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis ????Science http://www.kidney.de/pget.php?&tw=1&pmid=25766237 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25766237 #FOAvip English Wikipedia <ref>{{Cite pmid|25766237}}</ref> Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis #MMPMID25766237 Weber GF; Chousterman BG; He S; Fenn AM; Nairz M; Anzai A; Brenner T; Uhle F; Iwamoto Y; Robbins CS; Noiret L; Maier SL; Zonnchen T; Rahbari NN; Scholch S; Klotzsche-von Ameln A; Chavakis T; Weitz J; Hofer S; Weigand MA; Nahrendorf M; Weissleder R; Swirski FK Science 2015[Mar]; 347 (6227): 1260-5 PMID25766237show ga Sepsis is a frequently fatal condition characterized by an uncontrolled and harmful host reaction to microbial infection. Despite the prevalence and severity of sepsis, we lack a fundamental grasp of its pathophysiology. Here we report that the cytokine interleukin-3 (IL-3) potentiates inflammation in sepsis. Using a mouse model of abdominal sepsis, we showed that innate response activator B cells produce IL-3, which induces myelopoiesis of Ly-6C(high) monocytes and neutrophils and fuels a cytokine storm. IL-3 deficiency protects mice against sepsis. In humans with sepsis, high plasma IL-3 levels are associated with high mortality even after adjusting for prognostic indicators. This study deepens our understanding of immune activation, identifies IL-3 as an orchestrator of emergency myelopoiesis, and reveals a new therapeutic target for treating sepsis. |Animals[MESH] |B-Lymphocyte Subsets/immunology[MESH] |Cytokines/immunology/metabolism[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Inflammation[MESH] |Interleukin-3/blood/*immunology/metabolism[MESH] |Lipopolysaccharides/immunology[MESH] |Lymphoid Tissue/immunology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Monocytes/immunology[MESH] |Myelopoiesis[MESH] |Neutrophils/immunology[MESH] |Peritonitis/immunology/pathology[MESH] |Prognosis[MESH]Interleukin-3 amplifies acute inflammation and is a potential therapeu(epmc).pdf DeepDyve Pubget Overpricing