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10.1016/0001-706x(89)90047-8 http://scihub22266oqcxt.onion/10.1016/0001-706x(89)90047-8 2575870!ä!2575870 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Trop 1989 ; 46 (5-6): 351-9 Nephropedia Template TP {{tp|p=2575870|t=1989. Immunological alterations in uncomplicated Plasmodium falciparum malaria Relationship between parasitaemia and indicators of macrophage activation |pdf=|usr=}}{{2575870}} gab.com Text Immunological alterations in uncomplicated Plasmodium falciparum malaria Relationship between parasitaemia and indicators of macrophage activation JO: Acta Trop http://www.kidney.de/pget.php?&tw=1&pmid=2575870 #FOAvip Numerical alterations of circulating lymphocytes were investigated in 37 Brazilian patients with uncomplicated Plasmodium falciparum malaria and in a group of 15 healthy controls. The number of CD4+ T helper/inducer cells was significantly lower in patients than controls, whereas absolute numbers of CD8+ suppressor/cytotoxic T cells did not differ between the groups. TNF and neopterin levels were markedly increased in the plasma of patients and remained slightly elevated after chemotherapy with clindamycin. Neopterin, but not TNF levels, were significantly correlated with parasitaemia. TNF was inversely related to monocyte counts. Interferon gamma could not be detected in the plasma of control subjects and was observed in only one patient. We conclude that in uncomplicated falciparum malaria the distribution of phenotypes of circulating lymphocytes are altered slightly and that the high plasma levels of TNF and neopterin indicate excessive release of these molecules by activated macrophages and the activation of cellular immune mechanisms during the infection. Twit Text FOAVip Immunological alterations in uncomplicated Plasmodium falciparum malaria Relationship between parasitaemia and indicators of macrophage activation ????Acta Trop http://www.kidney.de/pget.php?&tw=1&pmid=2575870 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2575870 #FOAvip English Wikipedia <ref>{{Cite pmid|2575870}}</ref> Immunological alterations in uncomplicated Plasmodium falciparum malaria Relationship between parasitaemia and indicators of macrophage activation #MMPMID2575870 Kremsner PG; Feldmeier H; Zotter GM; Jansen-Rosseck R; Graninger W; Rocha RM; Bienzle U Acta Trop 1989[Oct]; 46 (5-6): 351-9 PMID2575870show ga Numerical alterations of circulating lymphocytes were investigated in 37 Brazilian patients with uncomplicated Plasmodium falciparum malaria and in a group of 15 healthy controls. The number of CD4+ T helper/inducer cells was significantly lower in patients than controls, whereas absolute numbers of CD8+ suppressor/cytotoxic T cells did not differ between the groups. TNF and neopterin levels were markedly increased in the plasma of patients and remained slightly elevated after chemotherapy with clindamycin. Neopterin, but not TNF levels, were significantly correlated with parasitaemia. TNF was inversely related to monocyte counts. Interferon gamma could not be detected in the plasma of control subjects and was observed in only one patient. We conclude that in uncomplicated falciparum malaria the distribution of phenotypes of circulating lymphocytes are altered slightly and that the high plasma levels of TNF and neopterin indicate excessive release of these molecules by activated macrophages and the activation of cellular immune mechanisms during the infection. |Adolescent[MESH] |Adult[MESH] |Animals[MESH] |Biopterins/analogs & derivatives/analysis[MESH] |CD4-Positive T-Lymphocytes[MESH] |Clindamycin/therapeutic use[MESH] |Female[MESH] |Humans[MESH] |Leukocyte Count[MESH] |Lymphocytes[MESH] |Macrophage Activation/*immunology[MESH] |Malaria/drug therapy/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes[MESH] |Neopterin[MESH] |Plasmodium falciparum/immunology[MESH] |Regression Analysis[MESH] |T-Lymphocytes, Helper-Inducer[MESH] |T-Lymphocytes, Regulatory[MESH]Immunological alterations in uncomplicated Plasmodium falciparum malar(epmc).pdf DeepDyve Pubget Overpricing