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10.3945/jn.114.203489 http://scihub22266oqcxt.onion/10.3945/jn.114.203489 25733456!4336527!25733456     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25733456&cmd=llinks): Failed to open stream: HTTP request failed! 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Genetic variations in magnesium-related ion channels may affect diabetes risk among African American and Hispanic American women |pdf=|usr=}}{{25733456}} gab.com Text Genetic variations in magnesium-related ion channels may affect diabetes risk among African American and Hispanic American women JO: J Nutr http://www.kidney.de/pget.php?&tw=1&pmid=25733456 #FOAvip BACKGROUND: Prospective studies consistently link low magnesium intake to higher type 2 diabetes (T2D) risk. OBJECTIVE: We examined the association of common genetic variants [single nucleotide polymorphisms (SNPs)] in genes related to magnesium homeostasis with T2D risk and potential interactions with magnesium intake. METHODS: Using the Women's Health Initiative-SNP Health Association Resource (WHI-SHARe) study, we identified 17 magnesium-related ion channel genes (583 SNPs) and examined their associations with T2D risk in 7287 African-American (AA; n = 1949 T2D cases) and 3285 Hispanic-American (HA; n = 611 T2D cases) postmenopausal women. We performed both single- and multiple-locus haplotype analyses. RESULTS: Among AA women, carriers of each additional copy of SNP rs6584273 in cyclin mediator 1 (CNNM1) had 16% lower T2D risk [OR: 0.84; false discovery rate (FDR)-adjusted P = 0.02]. Among HA women, several variants were significantly associated with T2D risk, including rs10861279 in solute carrier family 41 (anion exchanger), member 2 (SLC41A2) (OR: 0.54; FDR-adjusted P = 0.04), rs7174119 in nonimprinted in Prader-Willi/Angelman syndrome 1 (NIPA1) (OR: 1.27; FDR-adjusted P = 0.04), and 2 SNPs in mitochondrial RNA splicing 2 (MRS2) (rs7738943: OR = 1.55, FDR-adjusted P = 0.01; rs1056285: OR = 1.48, FDR-adjusted P = 0.02). Even with the most conservative Bonferroni adjustment, two 2-SNP-haplotypes in SLC41A2 and MRS2 region were significantly associated with T2D risk (rs12582312-rs10861279: P = 0.0006; rs1056285-rs7738943: P = 0.002). Among women with magnesium intake in the lowest 30% (AA: </=0.164 g/d; HA: </=0.185 g/d), 4 SNP signals were strengthened [rs11590362 in claudin 19 (CLDN19), rs823154 in SLC41A1, rs5929706 and rs5930817 in membra; HA: >/=0.313 g/d), rs6584273 in CNNM1 (OR: 0.71; FDR-adjusted P = 0.04) and rs1800467 in potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) (OR: 2.50; FDR-adjusted P = 0.01) were significantly associated with T2D risk. CONCLUSIONS: Our findings suggest important associations between genetic variations in magnesium-related ion channel genes and T2D risk in AA and HA women that vary by amount of magnesium intake. Twit Text FOAVip Genetic variations in magnesium-related ion channels may affect diabetes risk among African American and Hispanic American women ????J Nutr http://www.kidney.de/pget.php?&tw=1&pmid=25733456 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25733456 #FOAvip English Wikipedia <ref>{{Cite pmid|25733456}}</ref> Genetic variations in magnesium-related ion channels may affect diabetes risk among African American and Hispanic American women #MMPMID25733456 Chan KH; Chacko SA; Song Y; Cho M; Eaton CB; Wu WC; Liu S J Nutr 2015[Mar]; 145 (3): 418-24 PMID25733456show ga BACKGROUND: Prospective studies consistently link low magnesium intake to higher type 2 diabetes (T2D) risk. OBJECTIVE: We examined the association of common genetic variants [single nucleotide polymorphisms (SNPs)] in genes related to magnesium homeostasis with T2D risk and potential interactions with magnesium intake. METHODS: Using the Women's Health Initiative-SNP Health Association Resource (WHI-SHARe) study, we identified 17 magnesium-related ion channel genes (583 SNPs) and examined their associations with T2D risk in 7287 African-American (AA; n = 1949 T2D cases) and 3285 Hispanic-American (HA; n = 611 T2D cases) postmenopausal women. We performed both single- and multiple-locus haplotype analyses. RESULTS: Among AA women, carriers of each additional copy of SNP rs6584273 in cyclin mediator 1 (CNNM1) had 16% lower T2D risk [OR: 0.84; false discovery rate (FDR)-adjusted P = 0.02]. Among HA women, several variants were significantly associated with T2D risk, including rs10861279 in solute carrier family 41 (anion exchanger), member 2 (SLC41A2) (OR: 0.54; FDR-adjusted P = 0.04), rs7174119 in nonimprinted in Prader-Willi/Angelman syndrome 1 (NIPA1) (OR: 1.27; FDR-adjusted P = 0.04), and 2 SNPs in mitochondrial RNA splicing 2 (MRS2) (rs7738943: OR = 1.55, FDR-adjusted P = 0.01; rs1056285: OR = 1.48, FDR-adjusted P = 0.02). Even with the most conservative Bonferroni adjustment, two 2-SNP-haplotypes in SLC41A2 and MRS2 region were significantly associated with T2D risk (rs12582312-rs10861279: P = 0.0006; rs1056285-rs7738943: P = 0.002). Among women with magnesium intake in the lowest 30% (AA: /=0.313 g/d), rs6584273 in CNNM1 (OR: 0.71; FDR-adjusted P = 0.04) and rs1800467 in potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) (OR: 2.50; FDR-adjusted P = 0.01) were significantly associated with T2D risk. CONCLUSIONS: Our findings suggest important associations between genetic variations in magnesium-related ion channel genes and T2D risk in AA and HA women that vary by amount of magnesium intake. |*Polymorphism, Single Nucleotide[MESH] |Aged[MESH] |Black or African American/*genetics[MESH] |Body Mass Index[MESH] |Case-Control Studies[MESH] |Cation Transport Proteins/genetics[MESH] |Claudins/genetics[MESH] |Diabetes Mellitus, Type 2/blood/*genetics[MESH] |Dietary Supplements[MESH] |Female[MESH] |Genetic Loci[MESH] |Genetic Predisposition to Disease[MESH] |Genome-Wide Association Study[MESH] |Genotyping Techniques[MESH] |Haplotypes[MESH] |Hispanic or Latino/*genetics[MESH] |Humans[MESH] |Ion Channels/*genetics[MESH] |Logistic Models[MESH] |Magnesium/*administration & dosage/blood[MESH] |Middle Aged[MESH] |Postmenopause[MESH] |Potassium Channels, Inwardly Rectifying/genetics[MESH] |Prospective Studies[MESH]Genetic variations in magnesium-related ion channels may affect diabet(epmc).pdf DeepDyve Pubget Overpricing