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10.1155/2015/587135 http://scihub22266oqcxt.onion/10.1155/2015/587135 25710007!4331404!25710007     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25710007&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Biomed+Res+Int 2015 ; 2015 (?): 587135 Nephropedia Template TP {{tp|p=25710007|t=2015. Calcium channel expression and applicability as targeted therapies in melanoma |pdf=|usr=}}{{25710007}} gab.com Text Calcium channel expression and applicability as targeted therapies in melanoma JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=25710007 #FOAvip The remodeling of Ca(2+) signaling is a common finding in cancer pathophysiology serving the purpose of facilitating proliferation, migration, or survival of cancer cells subjected to stressful conditions. One particular facet of these adaptive changes is the alteration of Ca(2+) fluxes through the plasma membrane, as described in several studies. In this review, we summarize the current knowledge about the expression of different Ca(2+) channels in the plasma membrane of melanoma cells and its impact on oncogenic Ca(2+) signaling. In the last few years, new molecular components of Ca(2+) influx pathways have been identified in melanoma cells. In addition, new links between Ca(2+) homeostasis and specific cell processes important in melanoma tumor progression have been unveiled. Thus, not only do Ca(2+) channels appear to have a potential as prognostic markers, but their pharmacological blockade or gene silencing is hinted as interesting therapeutic approaches. Twit Text FOAVip Calcium channel expression and applicability as targeted therapies in melanoma ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=25710007 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25710007 #FOAvip English Wikipedia <ref>{{Cite pmid|25710007}}</ref> Calcium channel expression and applicability as targeted therapies in melanoma #MMPMID25710007 Macia A; Herreros J; Marti RM; Canti C Biomed Res Int 2015[]; 2015 (?): 587135 PMID25710007show ga The remodeling of Ca(2+) signaling is a common finding in cancer pathophysiology serving the purpose of facilitating proliferation, migration, or survival of cancer cells subjected to stressful conditions. One particular facet of these adaptive changes is the alteration of Ca(2+) fluxes through the plasma membrane, as described in several studies. In this review, we summarize the current knowledge about the expression of different Ca(2+) channels in the plasma membrane of melanoma cells and its impact on oncogenic Ca(2+) signaling. In the last few years, new molecular components of Ca(2+) influx pathways have been identified in melanoma cells. In addition, new links between Ca(2+) homeostasis and specific cell processes important in melanoma tumor progression have been unveiled. Thus, not only do Ca(2+) channels appear to have a potential as prognostic markers, but their pharmacological blockade or gene silencing is hinted as interesting therapeutic approaches. |Animals[MESH] |Antineoplastic Agents/administration & dosage[MESH] |Calcium Channel Blockers/*administration & dosage[MESH] |Calcium Channels/*metabolism[MESH] |Calcium Signaling/drug effects[MESH] |Humans[MESH] |Melanoma/*drug therapy/*metabolism[MESH] |Models, Biological[MESH] |Molecular Targeted Therapy/methods[MESH]Calcium channel expression and applicability as targeted therapies in (epmc).pdf DeepDyve Pubget Overpricing