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suck abstract from ncbi


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pmid2570513      Acta+Virol 1989 ; 33 (3): 262-9
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  • The role of suppressive macrophages in influenza virus-induced immunosuppression #MMPMID2570513
  • Ichikawa K; Miura R
  • Acta Virol 1989[May]; 33 (3): 262-9 PMID2570513show ga
  • To confirm the role of macrophages in influenza virus (IV)-induced immunosuppression (IS) of mice, silica, a selectively destructive agent for macrophages, was tested for its ability to influence the IV-induced IS. Silica completely abolished that effect. In contrast, Indomethacin--a prostaglandin inhibitor--did not influence the IV-induced IS. Peritoneal macrophages of mice infected with IV were suppressive for plaque forming cell (PFC) response of normal spleen cells in vitro. The assumption was made that suppressive macrophages were induced by IV in mice. However, no suppressive factors were found in the culture fluid of these cells.
  • |*Immune Tolerance[MESH]
  • |Animals[MESH]
  • |Carboxylesterase[MESH]
  • |Carboxylic Ester Hydrolases/analysis[MESH]
  • |Female[MESH]
  • |Immunization, Passive[MESH]
  • |Indomethacin/pharmacology[MESH]
  • |Macrophages/*physiology[MESH]
  • |Mice[MESH]
  • |Mice, Inbred BALB C[MESH]
  • |Orthomyxoviridae/*immunology[MESH]
  • |Phagocytosis[MESH]
  • |Silicon Dioxide/pharmacology[MESH]


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