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10.1007/s10753-015-0140-2 http://scihub22266oqcxt.onion/10.1007/s10753-015-0140-2 25691139!ä!25691139 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25691139&cmd=llinks): Failed to open stream: HTTP request failed! 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Anti-inflammatory Activity of Magnesium Isoglycyrrhizinate Through Inhibition of Phospholipase A2/Arachidonic Acid Pathway |pdf=|usr=}}{{25691139}} gab.com Text Anti-inflammatory Activity of Magnesium Isoglycyrrhizinate Through Inhibition of Phospholipase A2/Arachidonic Acid Pathway JO: Inflammation http://www.kidney.de/pget.php?&tw=1&pmid=25691139 #FOAvip Glycyrrhiza glabra (licorice) has been known to possess various pharmacological properties including anti-inflammatory, antioxidants, antiviral, and hepatoprotective activities. Magnesium isoglycyrrhizinate (MgIG), a magnesium salt of 18-alpha glycyrrhizic acid stereoisomer, is clinically used for the treatment of inflammatory liver diseases. However, the mechanism by which MgIG exerts its anti-inflammatory effects remains unknown. In the present study, we investigated the inhibitory potential of MgIG in phospholipase A2 (PLA2)/arachidonic acid (AA) pathway and release of the pathway-generated inflammatory lipid mediators in RAW264.7 macrophages. Results revealed that MgIG suppressed LPS-induced activation of PLA2 and production of AA metabolites such as prostaglandin E2 (PGE2), prostacyclin (PGI2), thromboxane 2 (TXB2), and leukotrienes (LTB4) in macrophages. Furthermore, LPS-induced AA-metabolizing enzymes including COX-2, COX-1, 5-LOX, TXB synthase, and PGI2 synthase were significantly inhibited by MgIG. Taken together, our data suggest that modulation of cyclooxygenase (COXs) and 5-lipoxygenase (LOX) pathways in AA metabolism could be a novel mechanism for the anti-inflammatory effects of MgIG. Twit Text FOAVip Anti-inflammatory Activity of Magnesium Isoglycyrrhizinate Through Inhibition of Phospholipase A2/Arachidonic Acid Pathway ????Inflammation http://www.kidney.de/pget.php?&tw=1&pmid=25691139 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25691139 #FOAvip English Wikipedia <ref>{{Cite pmid|25691139}}</ref> Anti-inflammatory Activity of Magnesium Isoglycyrrhizinate Through Inhibition of Phospholipase A2/Arachidonic Acid Pathway #MMPMID25691139 Xie C; Li X; Wu J; Liang Z; Deng F; Xie W; Zhu M; Zhu J; Zhu W; Geng S; Zhong C Inflammation 2015[Aug]; 38 (4): 1639-48 PMID25691139show ga Glycyrrhiza glabra (licorice) has been known to possess various pharmacological properties including anti-inflammatory, antioxidants, antiviral, and hepatoprotective activities. Magnesium isoglycyrrhizinate (MgIG), a magnesium salt of 18-alpha glycyrrhizic acid stereoisomer, is clinically used for the treatment of inflammatory liver diseases. However, the mechanism by which MgIG exerts its anti-inflammatory effects remains unknown. In the present study, we investigated the inhibitory potential of MgIG in phospholipase A2 (PLA2)/arachidonic acid (AA) pathway and release of the pathway-generated inflammatory lipid mediators in RAW264.7 macrophages. Results revealed that MgIG suppressed LPS-induced activation of PLA2 and production of AA metabolites such as prostaglandin E2 (PGE2), prostacyclin (PGI2), thromboxane 2 (TXB2), and leukotrienes (LTB4) in macrophages. Furthermore, LPS-induced AA-metabolizing enzymes including COX-2, COX-1, 5-LOX, TXB synthase, and PGI2 synthase were significantly inhibited by MgIG. Taken together, our data suggest that modulation of cyclooxygenase (COXs) and 5-lipoxygenase (LOX) pathways in AA metabolism could be a novel mechanism for the anti-inflammatory effects of MgIG. |Animals[MESH] |Anti-Inflammatory Agents/*pharmacology[MESH] |Arachidonic Acid/antagonists & inhibitors/*metabolism[MESH] |Cell Line[MESH] |Drugs, Chinese Herbal/*pharmacology[MESH] |Macrophages/drug effects/metabolism[MESH] |Mice[MESH] |Phospholipases A2/*metabolism[MESH] |Saponins/*pharmacology[MESH] |Signal Transduction/*drug effects/physiology[MESH]Anti-inflammatory Activity of Magnesium Isoglycyrrhizinate Through Inh(epmc).pdf DeepDyve Pubget Overpricing