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10.1016/S1567-5688(15)50006-8 http://scihub22266oqcxt.onion/10.1016/S1567-5688(15)50006-8 25659873!ä!25659873 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Atheroscler+Suppl 2015 ; 17 (ä): 23-6 Nephropedia Template TP {{tp|p=25659873|t=2015. The role of PCSK9 in intestinal lipoprotein metabolism: synergism of statin and ezetimibe |pdf=|usr=}}{{25659873}} gab.com Text The role of PCSK9 in intestinal lipoprotein metabolism: synergism of statin and ezetimibe JO: Atheroscler Suppl http://www.kidney.de/pget.php?&tw=1&pmid=25659873 #FOAvip Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a major role in the regulation of lipoprotein metabolism, mostly through control of low-density lipoprotein receptor degradation. Depletion of cellular cholesterol causes a compensatory increase in plasma PCSK9 levels, which can diminish the cholesterol-lowering power of statins and may lead to the overproduction of intestinal lipoproteins, mainly thorough the up regulation of microsomal triglyceride transfer protein and the Niemann-Pick C1-like 1 protein, the target of ezetimibe. Thus, ezetimibe therapy may counter this unwanted effect of statins, providing an additional theoretical rationale for combining the effect of ezetimibe on intestinal cholesterol absorption and that of statins on cholesterol synthesis. Twit Text FOAVip The role of PCSK9 in intestinal lipoprotein metabolism: synergism of statin and ezetimibe ????Atheroscler Suppl http://www.kidney.de/pget.php?&tw=1&pmid=25659873 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25659873 #FOAvip English Wikipedia <ref>{{Cite pmid|25659873}}</ref> The role of PCSK9 in intestinal lipoprotein metabolism: synergism of statin and ezetimibe #MMPMID25659873 Fazio S Atheroscler Suppl 2015[Feb]; 17 (ä): 23-6 PMID25659873show ga Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a major role in the regulation of lipoprotein metabolism, mostly through control of low-density lipoprotein receptor degradation. Depletion of cellular cholesterol causes a compensatory increase in plasma PCSK9 levels, which can diminish the cholesterol-lowering power of statins and may lead to the overproduction of intestinal lipoproteins, mainly thorough the up regulation of microsomal triglyceride transfer protein and the Niemann-Pick C1-like 1 protein, the target of ezetimibe. Thus, ezetimibe therapy may counter this unwanted effect of statins, providing an additional theoretical rationale for combining the effect of ezetimibe on intestinal cholesterol absorption and that of statins on cholesterol synthesis. |Animals[MESH] |Azetidines/adverse effects/*therapeutic use[MESH] |Cholesterol/blood[MESH] |Drug Combinations[MESH] |Drug Synergism[MESH] |Dyslipidemias/blood/diagnosis/*drug therapy/enzymology[MESH] |Ezetimibe, Simvastatin Drug Combination[MESH] |Humans[MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects/*therapeutic use[MESH] |Intestinal Absorption/drug effects[MESH] |Intestines/*drug effects/enzymology[MESH] |Lipoproteins/*blood[MESH] |Proprotein Convertase 9[MESH] |Proprotein Convertases/*metabolism[MESH] |Receptors, LDL/drug effects/metabolism[MESH] |Serine Endopeptidases/*metabolism[MESH] |Simvastatin/adverse effects/*therapeutic use[MESH]The role of PCSK9 in intestinal lipoprotein metabolism: synergism of s(epmc).pdf DeepDyve Pubget Overpricing