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http://scihub22266oqcxt.onion/ 2565083/?report=reader!1715646!2565083     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Hum+Genet 1989 ; 44 (5): 720-3 Nephropedia Template TP {{tp|p=2565083|t=1989. Genetic linkage of Beckwith-Wiedemann syndrome to 11p15 |pdf=|usr=}}{{2565083}} gab.com Text Genetic linkage of Beckwith-Wiedemann syndrome to 11p15 JO: Am J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=2565083 #FOAvip Beckwith-Wiedemann syndrome (BWS), characterized by multiorgan developmental abnormalities and predisposition to cancer, usually occurs sporadically, but small apparently dominant pedigrees have been described. Since rare patients show varying karyotypic abnormalities on the short arm of chromosome 11, it has been suggested that BWS may be related to the Wilms tumor gene on 11p13 or, alternatively, to growth factor genes on 11p15. We performed genetic linkage analysis on two BWS kindreds, using RFLPs for loci on 11p. BWS was linked to the insulin gene (11p15.5), with an overall maximum lod score of 3.60 (recombination fraction = .00). Linkage to D11S16 (11p13) could be excluded for recombination fractions less than or equal to .03. These results suggest that BWS defines a tumor-predisposition gene on 11p15. Twit Text FOAVip Genetic linkage of Beckwith-Wiedemann syndrome to 11p15 ????Am J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=2565083 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2565083 #FOAvip English Wikipedia <ref>{{Cite pmid|2565083}}</ref> Genetic linkage of Beckwith-Wiedemann syndrome to 11p15 #MMPMID2565083 Ping AJ; Reeve AE; Law DJ; Young MR; Boehnke M; Feinberg AP Am J Hum Genet 1989[May]; 44 (5): 720-3 PMID2565083show ga Beckwith-Wiedemann syndrome (BWS), characterized by multiorgan developmental abnormalities and predisposition to cancer, usually occurs sporadically, but small apparently dominant pedigrees have been described. Since rare patients show varying karyotypic abnormalities on the short arm of chromosome 11, it has been suggested that BWS may be related to the Wilms tumor gene on 11p13 or, alternatively, to growth factor genes on 11p15. We performed genetic linkage analysis on two BWS kindreds, using RFLPs for loci on 11p. BWS was linked to the insulin gene (11p15.5), with an overall maximum lod score of 3.60 (recombination fraction = .00). Linkage to D11S16 (11p13) could be excluded for recombination fractions less than or equal to .03. These results suggest that BWS defines a tumor-predisposition gene on 11p15. |*Chromosomes, Human, Pair 11[MESH] |*Genetic Linkage[MESH] |*Lod Score[MESH] |*Polymorphism, Genetic[MESH] |*Polymorphism, Restriction Fragment Length[MESH] |Beckwith-Wiedemann Syndrome/*genetics[MESH] |Female[MESH] |Genes, Dominant[MESH] |Humans[MESH] |Infant, Newborn[MESH] |Insulin/genetics[MESH] |Male[MESH] |Pedigree[MESH]Genetic linkage of Beckwith-Wiedemann syndrome to 11p15 (epmc).pdf DeepDyve Pubget Overpricing