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10.1016/j.taap.2015.01.008 http://scihub22266oqcxt.onion/10.1016/j.taap.2015.01.008 25617811!ä!25617811 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxicol+Appl+Pharmacol 2015 ; 283 (2): 147-55 Nephropedia Template TP {{tp|p=25617811|t=2015. Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor |pdf=|usr=}}{{25617811}} gab.com Text Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor JO: Toxicol Appl Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25617811 #FOAvip Allergic contact dermatitis (ACD) is a cell-mediated immune response that involves skin sensitization in response to contact with various allergens. Angiogenesis and lymphangiogenesis both play roles in the allergic sensitization process. Epidermal keratinocytes can produce vascular endothelial growth factor (VEGF) in response to UV irradiation and during wound healing. However, the effect of haptenic chemical allergens on the VEGF production of human keratinocytes, which is the primary contact site of toxic allergens, has not been thoroughly researched. We systematically investigated whether immune-regulatory cytokines and chemical allergens would lead to the production of VEGF in normal human keratinocytes (NHKs) in culture. VEGF production significantly increased when NHKs were treated with IFNgamma, IL-1alpha, IL-4, IL-6, IL-17A, IL-22 or TNFalpha. Among the human sensitizers listed in the OECD Test Guideline (TG) 429, we found that CMI/MI, DNCB, 4-phenylenediamine, cobalt chloride, 2-mercaptobenzothiazole, citral, HCA, cinnamic alcohol, imidazolidinyl urea and nickel chloride all significantly upregulated VEGF production in NHKs. In addition, common human haptenic allergens such as avobenzone, formaldehyde and urushiol, also induced the keratinocyte-derived VEGF production. VEGF upregulation by pro-inflammatory stimuli, IFNgamma, DNCB or formaldehyde is preceded by the production of IL-8, an acute inflammatory phase cytokine. Lymphangiogenic VEGF-C gene transcription was significantly increased when NHKs were treated with formaldehyde, DNCB or urushiol, while transcription of VEGF-A and VEGF-B did not change. Therefore, the chemical allergen-induced VEGF upregulation is mainly due to the increase in lymphangiogenic VEGF-C transcription in NHKs. These results suggest that keratinocyte-derived VEGF may regulate the lymphangiogenic process during the skin sensitization process of ACD. Twit Text FOAVip Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor ????Toxicol Appl Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25617811 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25617811 #FOAvip English Wikipedia <ref>{{Cite pmid|25617811}}</ref> Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor #MMPMID25617811 Bae ON; Ahn S; Jin SH; Hong SH; Lee J; Kim ES; Jeong TC; Chun YJ; Lee AY; Noh M Toxicol Appl Pharmacol 2015[Mar]; 283 (2): 147-55 PMID25617811show ga Allergic contact dermatitis (ACD) is a cell-mediated immune response that involves skin sensitization in response to contact with various allergens. Angiogenesis and lymphangiogenesis both play roles in the allergic sensitization process. Epidermal keratinocytes can produce vascular endothelial growth factor (VEGF) in response to UV irradiation and during wound healing. However, the effect of haptenic chemical allergens on the VEGF production of human keratinocytes, which is the primary contact site of toxic allergens, has not been thoroughly researched. We systematically investigated whether immune-regulatory cytokines and chemical allergens would lead to the production of VEGF in normal human keratinocytes (NHKs) in culture. VEGF production significantly increased when NHKs were treated with IFNgamma, IL-1alpha, IL-4, IL-6, IL-17A, IL-22 or TNFalpha. Among the human sensitizers listed in the OECD Test Guideline (TG) 429, we found that CMI/MI, DNCB, 4-phenylenediamine, cobalt chloride, 2-mercaptobenzothiazole, citral, HCA, cinnamic alcohol, imidazolidinyl urea and nickel chloride all significantly upregulated VEGF production in NHKs. In addition, common human haptenic allergens such as avobenzone, formaldehyde and urushiol, also induced the keratinocyte-derived VEGF production. VEGF upregulation by pro-inflammatory stimuli, IFNgamma, DNCB or formaldehyde is preceded by the production of IL-8, an acute inflammatory phase cytokine. Lymphangiogenic VEGF-C gene transcription was significantly increased when NHKs were treated with formaldehyde, DNCB or urushiol, while transcription of VEGF-A and VEGF-B did not change. Therefore, the chemical allergen-induced VEGF upregulation is mainly due to the increase in lymphangiogenic VEGF-C transcription in NHKs. These results suggest that keratinocyte-derived VEGF may regulate the lymphangiogenic process during the skin sensitization process of ACD. |Allergens/*pharmacology[MESH] |Animals[MESH] |Cell Survival/drug effects/physiology[MESH] |Cells, Cultured[MESH] |Dose-Response Relationship, Drug[MESH] |Epidermis/drug effects/immunology/*metabolism[MESH] |Foreskin/drug effects/immunology/metabolism[MESH] |Humans[MESH] |Keratinocytes/drug effects/immunology/*metabolism[MESH] |Lymphangiogenesis/drug effects/*physiology[MESH] |Male[MESH] |Mice[MESH]Chemical allergens stimulate human epidermal keratinocytes to produce (epmc).pdf DeepDyve Pubget Overpricing