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10.1152/physrev.00016.2014 http://scihub22266oqcxt.onion/10.1152/physrev.00016.2014 25540142!4281587!25540142     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Physiol+Rev 2015 ; 95 (1): 179-217 Nephropedia Template TP {{tp|p=25540142|t=2015. Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels |pdf=|usr=}}{{25540142}} gab.com Text Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels JO: Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25540142 #FOAvip K(+) channels fulfill roles spanning from the control of excitability to the regulation of transepithelial transport. Here we review two groups of K(+) channels, pH-regulated K2P channels and the transport group of Kir channels. After considering advances in the molecular aspects of their gating based on structural and functional studies, we examine their participation in certain chosen physiological and pathophysiological scenarios. Crystal structures of K2P and Kir channels reveal rather unique features with important consequences for the gating mechanisms. Important tasks of these channels are discussed in kidney physiology and disease, K(+) homeostasis in the brain by Kir channel-equipped glia, and central functions in the hearing mechanism in the inner ear and in acid secretion by parietal cells in the stomach. K2P channels fulfill a crucial part in central chemoreception probably by virtue of their pH sensitivity and are central to adrenal secretion of aldosterone. Finally, some unorthodox behaviors of the selectivity filters of K2P channels might explain their normal and pathological functions. Although a great deal has been learned about structure, molecular details of gating, and physiological functions of K2P and Kir K(+)-transport channels, this has been only scratching at the surface. More molecular and animal studies are clearly needed to deepen our knowledge. Twit Text FOAVip Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels ????Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25540142 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25540142 #FOAvip English Wikipedia <ref>{{Cite pmid|25540142}}</ref> Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels #MMPMID25540142 Sepulveda FV; Pablo Cid L; Teulon J; Niemeyer MI Physiol Rev 2015[Jan]; 95 (1): 179-217 PMID25540142show ga K(+) channels fulfill roles spanning from the control of excitability to the regulation of transepithelial transport. Here we review two groups of K(+) channels, pH-regulated K2P channels and the transport group of Kir channels. After considering advances in the molecular aspects of their gating based on structural and functional studies, we examine their participation in certain chosen physiological and pathophysiological scenarios. Crystal structures of K2P and Kir channels reveal rather unique features with important consequences for the gating mechanisms. Important tasks of these channels are discussed in kidney physiology and disease, K(+) homeostasis in the brain by Kir channel-equipped glia, and central functions in the hearing mechanism in the inner ear and in acid secretion by parietal cells in the stomach. K2P channels fulfill a crucial part in central chemoreception probably by virtue of their pH sensitivity and are central to adrenal secretion of aldosterone. Finally, some unorthodox behaviors of the selectivity filters of K2P channels might explain their normal and pathological functions. Although a great deal has been learned about structure, molecular details of gating, and physiological functions of K2P and Kir K(+)-transport channels, this has been only scratching at the surface. More molecular and animal studies are clearly needed to deepen our knowledge. |Animals[MESH] |Gene Expression Regulation/physiology[MESH] |Humans[MESH] |Hydrogen-Ion Concentration[MESH] |Ion Channel Gating/*physiology[MESH] |Potassium Channels, Inwardly Rectifying/genetics/*metabolism[MESH]Molecular aspects of structure, gating, and physiology of pH-sensitive(epmc).pdf DeepDyve Pubget Overpricing