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10.1016/j.bbrc.2014.10.118 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2014.10.118 25450691!ä!25450691 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Res+Commun 2014 ; 454 (4): 547-53 Nephropedia Template TP {{tp|p=25450691|t=2014. TRPM7 is required for ovarian cancer cell growth, migration and invasion |pdf=|usr=}}{{25450691}} gab.com Text TRPM7 is required for ovarian cancer cell growth, migration and invasion JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=25450691 #FOAvip Our previous study demonstrated that the melastatin-related transient receptor potential channel 7 (TRPM7) was highly expressed in ovarian carcinomas and its overexpression was significantly associated with poor prognosis in ovarian cancer patients. However, the function of TRPM7 in ovarian cancer is mostly unknown. In this study, we examined the roles of TRPM7 in ovarian cancer cell proliferation, migration and invasion. We found that short hairpin RNA interference-mediated silence of TRPM7 significantly inhibited cell proliferation, colony formation, migration and invasion in multiple ovarian cancer cell lines. Mechanistic investigation revealed that silence of TRPM7 decreased phosphorylation levels of Akt, Src and p38 and increased filamentous actin and focal adhesion number in ovarian cancer cells. Thus, our results suggest that TRPM7 is required for proliferation, migration and invasion of ovarian cancer cells through regulating multiple signaling transduction pathways and the formation of focal adhesions. Twit Text FOAVip TRPM7 is required for ovarian cancer cell growth, migration and invasion ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=25450691 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25450691 #FOAvip English Wikipedia <ref>{{Cite pmid|25450691}}</ref> TRPM7 is required for ovarian cancer cell growth, migration and invasion #MMPMID25450691 Wang J; Liao QJ; Zhang Y; Zhou H; Luo CH; Tang J; Wang Y; Tang Y; Zhao M; Zhao XH; Zhang QY; Xiao L Biochem Biophys Res Commun 2014[Nov]; 454 (4): 547-53 PMID25450691show ga Our previous study demonstrated that the melastatin-related transient receptor potential channel 7 (TRPM7) was highly expressed in ovarian carcinomas and its overexpression was significantly associated with poor prognosis in ovarian cancer patients. However, the function of TRPM7 in ovarian cancer is mostly unknown. In this study, we examined the roles of TRPM7 in ovarian cancer cell proliferation, migration and invasion. We found that short hairpin RNA interference-mediated silence of TRPM7 significantly inhibited cell proliferation, colony formation, migration and invasion in multiple ovarian cancer cell lines. Mechanistic investigation revealed that silence of TRPM7 decreased phosphorylation levels of Akt, Src and p38 and increased filamentous actin and focal adhesion number in ovarian cancer cells. Thus, our results suggest that TRPM7 is required for proliferation, migration and invasion of ovarian cancer cells through regulating multiple signaling transduction pathways and the formation of focal adhesions. |*Cell Movement[MESH] |*Cell Proliferation[MESH] |Cell Line, Tumor[MESH] |Female[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Ovarian Neoplasms/*metabolism/*pathology[MESH] |Protein Serine-Threonine Kinases/*metabolism[MESH] |Signal Transduction[MESH]TRPM7 is required for ovarian cancer cell growth, migration and invasi(epmc).pdf DeepDyve Pubget Overpricing