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10.1016/j.antiviral.2014.11.003 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2014.11.003 25446340!ä!25446340 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antiviral+Res 2015 ; 113 (ä): 62-70 Nephropedia Template TP {{tp|p=25446340|t=2015. Baicalin inhibits autophagy induced by influenza A virus H3N2 |pdf=|usr=}}{{25446340}} gab.com Text Baicalin inhibits autophagy induced by influenza A virus H3N2 JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=25446340 #FOAvip Baicalin, a natural product isolated from Scutellariaradix, has been reported to have significant in vivo and in vitro anti-influenza virus activity, but the underlying mechanism remains poorly understood. In this study, we found that baicalin inhibited autophagy induced by influenza virus A3/Beijing/30/95 (H3N2) in both A549 and Ana-1 cells. The results showed that H3N2 induced autophagy by suppressing mTOR signaling pathway, which however could be significantly inhibited by baicalin. Baicalin could suppress the expression of Atg5-Atg12 complex and LC3-II, and attenuate autophagy induced by starvation. Thus, the inhibition of autophagy induced by virus may account for the antiviral activities of baicalin against H3N2. Autophagy may be a potential marker in developing novel anti-influenza drugs. Twit Text FOAVip Baicalin inhibits autophagy induced by influenza A virus H3N2 ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=25446340 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25446340 #FOAvip English Wikipedia <ref>{{Cite pmid|25446340}}</ref> Baicalin inhibits autophagy induced by influenza A virus H3N2 #MMPMID25446340 Zhu HY; Han L; Shi XL; Wang BL; Huang H; Wang X; Chen DF; Ju DW; Feng MQ Antiviral Res 2015[Jan]; 113 (ä): 62-70 PMID25446340show ga Baicalin, a natural product isolated from Scutellariaradix, has been reported to have significant in vivo and in vitro anti-influenza virus activity, but the underlying mechanism remains poorly understood. In this study, we found that baicalin inhibited autophagy induced by influenza virus A3/Beijing/30/95 (H3N2) in both A549 and Ana-1 cells. The results showed that H3N2 induced autophagy by suppressing mTOR signaling pathway, which however could be significantly inhibited by baicalin. Baicalin could suppress the expression of Atg5-Atg12 complex and LC3-II, and attenuate autophagy induced by starvation. Thus, the inhibition of autophagy induced by virus may account for the antiviral activities of baicalin against H3N2. Autophagy may be a potential marker in developing novel anti-influenza drugs. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Autophagy/*drug effects[MESH] |Cell Line[MESH] |Cell Line, Tumor[MESH] |Dogs[MESH] |Flavonoids/*pharmacology/toxicity[MESH] |Humans[MESH] |Influenza A Virus, H3N2 Subtype/*physiology[MESH] |Macrophages/virology[MESH] |Madin Darby Canine Kidney Cells[MESH] |Mice[MESH] |Real-Time Polymerase Chain Reaction[MESH] |Scutellaria[MESH] |Signal Transduction/drug effects[MESH]Baicalin inhibits autophagy induced by influenza A virus H3N2 (epmc).pdf DeepDyve Pubget Overpricing