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10.1111/febs.13163 http://scihub22266oqcxt.onion/10.1111/febs.13163 25429850!7163960!25429850     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+J 2015 ; 282 (3): 445-62 Nephropedia Template TP {{tp|p=25429850|t=2015. Components and regulation of nuclear transport processes |pdf=|usr=}}{{25429850}} gab.com Text Components and regulation of nuclear transport processes JO: FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=25429850 #FOAvip The spatial separation of DNA replication and gene transcription in the nucleus and protein translation in the cytoplasm is a uniform principle of eukaryotic cells. This compartmentalization imposes a requirement for a transport network of macromolecules to shuttle these components in and out of the nucleus. This nucleo-cytoplasmic transport of macromolecules is critical for both cell physiology and pathology. Consequently, investigating its regulation and disease-associated alterations can reveal novel therapeutic approaches to fight human diseases, such as cancer or viral infection. The characterization of the nuclear pore complex, the identification of transport signals and transport receptors, as well as the characterization of the Ran system (providing the energy source for efficient cargo transport) has greatly facilitated our understanding of the components, mechanisms and regulation of the nucleo-cytoplasmic transport of proteins in our cells. Here we review this knowledge with a specific emphasis on the selection of disease-relevant molecular targets for potential therapeutic intervention. Twit Text FOAVip Components and regulation of nuclear transport processes ????FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=25429850 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25429850 #FOAvip English Wikipedia <ref>{{Cite pmid|25429850}}</ref> Components and regulation of nuclear transport processes #MMPMID25429850 Cautain B; Hill R; de Pedro N; Link W FEBS J 2015[Feb]; 282 (3): 445-62 PMID25429850show ga The spatial separation of DNA replication and gene transcription in the nucleus and protein translation in the cytoplasm is a uniform principle of eukaryotic cells. This compartmentalization imposes a requirement for a transport network of macromolecules to shuttle these components in and out of the nucleus. This nucleo-cytoplasmic transport of macromolecules is critical for both cell physiology and pathology. Consequently, investigating its regulation and disease-associated alterations can reveal novel therapeutic approaches to fight human diseases, such as cancer or viral infection. The characterization of the nuclear pore complex, the identification of transport signals and transport receptors, as well as the characterization of the Ran system (providing the energy source for efficient cargo transport) has greatly facilitated our understanding of the components, mechanisms and regulation of the nucleo-cytoplasmic transport of proteins in our cells. Here we review this knowledge with a specific emphasis on the selection of disease-relevant molecular targets for potential therapeutic intervention. |Active Transport, Cell Nucleus/physiology[MESH] |Animals[MESH] |Biological Transport/physiology[MESH] |Cell Nucleus/*metabolism[MESH] |Humans[MESH] |Karyopherins/metabolism[MESH] |Models, Biological[MESH]Components and regulation of nuclear transport processes (epmc).pdf DeepDyve Pubget Overpricing