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10.1016/0024-3205(89)90327-5 http://scihub22266oqcxt.onion/10.1016/0024-3205(89)90327-5 2542710!?!2542710       Life+Sci 1989 ; 44 (20): 1483-9 Nephropedia Template TP {{tp|p=2542710|t=1989. Magnesium ion: a possible physiological regulator of aldosterone production |pdf=|usr=}}{{2542710}} gab.com Text Magnesium ion: a possible physiological regulator of aldosterone production JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=2542710 #FOAvip We examined the direct effect of magnesium ion on aldosterone production by adrenal cells using collagenase-dispersed zona-glomerulosa cells in rats. The effects of magnesium on aldosterone production stimulated by angiotensin II or ACTH were also investigated. Both magnesium sulphate (MgSO4) and magnesium chloride (MgCl2) (0 to 2 mM) decreased aldosterone production in a dose-dependent manner. In comparison with magnesium-free medium, 2 mM MgSO4 inhibited aldosterone production by 73% and MgCl2 by 65%. In addition, MgSO4 showed an inhibitory effect on aldosterone production stimulated by angiotensin II (10pM to 10nM), whereas it had no significant effect on aldosterone production due to ACTH stimulation (10pM to 10nM). These data suggest that magnesium has an inhibitory action on aldosterone production in vitro and may be a physiological regulator of aldosterone production. Twit Text FOAVip Magnesium ion: a possible physiological regulator of aldosterone production ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=2542710 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2542710 #FOAvip English Wikipedia <ref>{{Cite pmid|2542710}}</ref> Magnesium ion: a possible physiological regulator of aldosterone production #MMPMID2542710 Atarashi K; Matsuoka H; Takagi M; Sugimoto T Life Sci 1989[]; 44 (20): 1483-9 PMID2542710show ga We examined the direct effect of magnesium ion on aldosterone production by adrenal cells using collagenase-dispersed zona-glomerulosa cells in rats. The effects of magnesium on aldosterone production stimulated by angiotensin II or ACTH were also investigated. Both magnesium sulphate (MgSO4) and magnesium chloride (MgCl2) (0 to 2 mM) decreased aldosterone production in a dose-dependent manner. In comparison with magnesium-free medium, 2 mM MgSO4 inhibited aldosterone production by 73% and MgCl2 by 65%. In addition, MgSO4 showed an inhibitory effect on aldosterone production stimulated by angiotensin II (10pM to 10nM), whereas it had no significant effect on aldosterone production due to ACTH stimulation (10pM to 10nM). These data suggest that magnesium has an inhibitory action on aldosterone production in vitro and may be a physiological regulator of aldosterone production. |Adrenocorticotropic Hormone/pharmacology[MESH] |Aldosterone/*biosynthesis[MESH] |Angiotensin II/pharmacology[MESH] |Animals[MESH] |Cations, Divalent[MESH] |Female[MESH] |Magnesium Chloride[MESH] |Magnesium Sulfate/pharmacology[MESH] |Magnesium/*pharmacology[MESH] |Rats[MESH] |Rats, Inbred Strains[MESH]Magnesium ion: a possible physiological regulator of aldosterone produ(epmc).pdf DeepDyve Pubget Overpricing