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http://scihub22266oqcxt.onion/ 2541725!?!2541725       Biochem+Int 1989 ; 18 (1): 81-9 Nephropedia Template TP {{tp|p=2541725|t=1989. Effects of glycyrrhizin and glycyrrhetinic acid on (Na+ + K+)-ATPase of renal basolateral membranes in vitro |pdf=|usr=}}{{2541725}} gab.com Text Effects of glycyrrhizin and glycyrrhetinic acid on (Na+ + K+)-ATPase of renal basolateral membranes in vitro JO: Biochem Int http://www.kidney.de/pget.php?&tw=1&pmid=2541725 #FOAvip Studies were made on the direct effects of glycyrrhizin and its aglycone, glycyrrhetinic acid on the activities of (Na+ + K+)-ATPase and (Ca2+ + Mg2+)-ATPase, a membrane bound Na+ and Ca2+-extrusion pump enzyme of the basolateral membranes (BLM) of canine kidney. Glycyrrhetinic acid inhibited the activity of the Na+-pump enzyme dose-dependently (IC50 = 1.5 x 10(-4) M), but had no effect on that of the Ca2+-pump enzyme of kidney BLM and homogenates. Glycyrrhizin also inhibited the Na+-pump enzyme activity but had less effect (IC50 = 2 x 10(-3) M). The effects of these compounds were due to competitive inhibition with ATP binding to the enzyme (Ki = 12 microM) and so were different from that of ouabain, which inhibits the Na+-pump by binding to its extracellular K+-binding site. The direct effect of glycyrrhetinic acid on the membrane may be important role in the multiple actions of licorice. Twit Text FOAVip Effects of glycyrrhizin and glycyrrhetinic acid on (Na+ + K+)-ATPase of renal basolateral membranes in vitro ????Biochem Int http://www.kidney.de/pget.php?&tw=1&pmid=2541725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2541725 #FOAvip English Wikipedia <ref>{{Cite pmid|2541725}}</ref> Effects of glycyrrhizin and glycyrrhetinic acid on (Na+ + K+)-ATPase of renal basolateral membranes in vitro #MMPMID2541725 Itoh K; Hara T; Shiraishi T; Taniguchi K; Morimoto S; Onishi T Biochem Int 1989[Jan]; 18 (1): 81-9 PMID2541725show ga Studies were made on the direct effects of glycyrrhizin and its aglycone, glycyrrhetinic acid on the activities of (Na+ + K+)-ATPase and (Ca2+ + Mg2+)-ATPase, a membrane bound Na+ and Ca2+-extrusion pump enzyme of the basolateral membranes (BLM) of canine kidney. Glycyrrhetinic acid inhibited the activity of the Na+-pump enzyme dose-dependently (IC50 = 1.5 x 10(-4) M), but had no effect on that of the Ca2+-pump enzyme of kidney BLM and homogenates. Glycyrrhizin also inhibited the Na+-pump enzyme activity but had less effect (IC50 = 2 x 10(-3) M). The effects of these compounds were due to competitive inhibition with ATP binding to the enzyme (Ki = 12 microM) and so were different from that of ouabain, which inhibits the Na+-pump by binding to its extracellular K+-binding site. The direct effect of glycyrrhetinic acid on the membrane may be important role in the multiple actions of licorice. |Aldosterone/pharmacology[MESH] |Animals[MESH] |Ca(2+) Mg(2+)-ATPase/antagonists & inhibitors[MESH] |Calcium-Transporting ATPases/antagonists & inhibitors[MESH] |Cell Membrane/enzymology[MESH] |Dogs[MESH] |Glycyrrhetinic Acid/*analogs & derivatives/pharmacology[MESH] |Glycyrrhizic Acid[MESH] |Kidney/*enzymology[MESH] |Kinetics[MESH] |Ouabain/pharmacology[MESH] |Progesterone/pharmacology[MESH]Effects of glycyrrhizin and glycyrrhetinic acid on (Na+ + K+)-ATPase o(epmc).pdf DeepDyve Pubget Overpricing