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10.1136/jclinpath-2014-202441 http://scihub22266oqcxt.onion/10.1136/jclinpath-2014-202441 25378539!ä!25378539 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Pathol 2015 ; 68 (1): 57-63 Nephropedia Template TP {{tp|p=25378539|t=2015. Molecular pathology analyses of two fatal human infections of avian influenza A(H7N9) virus |pdf=|usr=}}{{25378539}} gab.com Text Molecular pathology analyses of two fatal human infections of avian influenza A(H7N9) virus JO: J Clin Pathol http://www.kidney.de/pget.php?&tw=1&pmid=25378539 #FOAvip AIMS: To investigate the histopathological manifestations of two fatal cases of H7N9 influenza A virus infection. METHODS: Pulmonary and hepatic specimens from two fatal cases of H7N9 influenza virus infection were examined using H&E staining. Additionally, in situ hybridisation was performed with probes (ViewRNA) targeting H7N9 RNA and IP-10, interleukin (IL)-6 mRNA. The distribution of surfactant protein A (SP-A), surfactant protein B (SP-B), CD3, CD4, CD8, CD68 and C4d were determined with immunohistochemistry. RESULTS: Apart from the typical diffuse alveolar damage and hyaline membrane observed in severe influenza infection, we detected H7N9 RNA and massive intrapulmonary production of IP-10 and IL-6 mRNA using in situ hybridisation. Hyperplasia of type II pneumocytes was observed by H&E staining and immunohistochemistry. Proliferating macrophages and clustered neutrophils in the infected lungs were observed, whereas T lymphocytes, especially CD4T helper cells, were markedly depleted. No obvious complement deposition was found in lung tissues. CONCLUSIONS: Our findings suggest that H7N9 influenza virus induced an immunological response towards overt pulmonary inflammation and systemic lymphopenia which led to intense alveolar damage and respiratory failure. Twit Text FOAVip Molecular pathology analyses of two fatal human infections of avian influenza A(H7N9) virus ????J Clin Pathol http://www.kidney.de/pget.php?&tw=1&pmid=25378539 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25378539 #FOAvip English Wikipedia <ref>{{Cite pmid|25378539}}</ref> Molecular pathology analyses of two fatal human infections of avian influenza A(H7N9) virus #MMPMID25378539 Feng Y; Hu L; Lu S; Chen Q; Zheng Y; Zeng D; Zhang J; Zhang A; Chen L; Hu Y; Zhang Z J Clin Pathol 2015[Jan]; 68 (1): 57-63 PMID25378539show ga AIMS: To investigate the histopathological manifestations of two fatal cases of H7N9 influenza A virus infection. METHODS: Pulmonary and hepatic specimens from two fatal cases of H7N9 influenza virus infection were examined using H&E staining. Additionally, in situ hybridisation was performed with probes (ViewRNA) targeting H7N9 RNA and IP-10, interleukin (IL)-6 mRNA. The distribution of surfactant protein A (SP-A), surfactant protein B (SP-B), CD3, CD4, CD8, CD68 and C4d were determined with immunohistochemistry. RESULTS: Apart from the typical diffuse alveolar damage and hyaline membrane observed in severe influenza infection, we detected H7N9 RNA and massive intrapulmonary production of IP-10 and IL-6 mRNA using in situ hybridisation. Hyperplasia of type II pneumocytes was observed by H&E staining and immunohistochemistry. Proliferating macrophages and clustered neutrophils in the infected lungs were observed, whereas T lymphocytes, especially CD4T helper cells, were markedly depleted. No obvious complement deposition was found in lung tissues. CONCLUSIONS: Our findings suggest that H7N9 influenza virus induced an immunological response towards overt pulmonary inflammation and systemic lymphopenia which led to intense alveolar damage and respiratory failure. |*Influenza A Virus, H7N9 Subtype[MESH] |Aged, 80 and over[MESH] |Animals[MESH] |Antigens, CD/analysis/biosynthesis[MESH] |Fatal Outcome[MESH] |Humans[MESH] |Immunohistochemistry[MESH] |In Situ Hybridization[MESH] |Influenza, Human/*immunology/*pathology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Pathology, Molecular[MESH]Molecular pathology analyses of two fatal human infections of avian in(epmc).pdf DeepDyve Pubget Overpricing