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10.1007/s00401-014-1349-0

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suck abstract from ncbi


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pmid25348064      Acta+Neuropathol 2014 ; 128 (6): 755-66
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  • Primary age-related tauopathy (PART): a common pathology associated with human aging #MMPMID25348064
  • Crary JF; Trojanowski JQ; Schneider JA; Abisambra JF; Abner EL; Alafuzoff I; Arnold SE; Attems J; Beach TG; Bigio EH; Cairns NJ; Dickson DW; Gearing M; Grinberg LT; Hof PR; Hyman BT; Jellinger K; Jicha GA; Kovacs GG; Knopman DS; Kofler J; Kukull WA; Mackenzie IR; Masliah E; McKee A; Montine TJ; Murray ME; Neltner JH; Santa-Maria I; Seeley WW; Serrano-Pozo A; Shelanski ML; Stein T; Takao M; Thal DR; Toledo JB; Troncoso JC; Vonsattel JP; White CL 3rd; Wisniewski T; Woltjer RL; Yamada M; Nelson PT
  • Acta Neuropathol 2014[Dec]; 128 (6): 755-66 PMID25348064show ga
  • We recommend a new term, "primary age-related tauopathy" (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains with neurofibrillary tangles (NFTs) that are indistinguishable from those of Alzheimer's disease (AD), in the absence of amyloid (Abeta) plaques. For these "NFT+/Abeta-" brains, for which formal criteria for AD neuropathologic changes are not met, the NFTs are mostly restricted to structures in the medial temporal lobe, basal forebrain, brainstem, and olfactory areas (bulb and cortex). Symptoms in persons with PART usually range from normal to amnestic cognitive changes, with only a minority exhibiting profound impairment. Because cognitive impairment is often mild, existing clinicopathologic designations, such as "tangle-only dementia" and "tangle-predominant senile dementia", are imprecise and not appropriate for most subjects. PART is almost universally detectable at autopsy among elderly individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time. Improved biomarkers and tau imaging may enable diagnosis of PART in clinical settings in the future. Indeed, recent studies have identified a common biomarker profile consisting of temporal lobe atrophy and tauopathy without evidence of Abeta accumulation. For both researchers and clinicians, a revised nomenclature will raise awareness of this extremely common pathologic change while providing a conceptual foundation for future studies. Prior reports that have elucidated features of the pathologic entity we refer to as PART are discussed, and working neuropathological diagnostic criteria are proposed.
  • |Aging/*pathology[MESH]
  • |Brain/*pathology[MESH]
  • |Diagnosis, Differential[MESH]
  • |Humans[MESH]
  • |Plaque, Amyloid/pathology[MESH]
  • |Tauopathies/classification/diagnosis/*pathology[MESH]


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