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10.1002/cbin.10397 http://scihub22266oqcxt.onion/10.1002/cbin.10397 25339500!ä!25339500 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Biol+Int 2015 ; 39 (3): 310-7 Nephropedia Template TP {{tp|p=25339500|t=2015. HGF expression induced by HIF-1alpha promote the proliferation and tube formation of endothelial progenitor cells |pdf=|usr=}}{{25339500}} gab.com Text HGF expression induced by HIF-1alpha promote the proliferation and tube formation of endothelial progenitor cells JO: Cell Biol Int http://www.kidney.de/pget.php?&tw=1&pmid=25339500 #FOAvip Hypoxia-inducible factor-1alpha (HIF-1alpha) and hepatocyte growth factor (HGF) play important roles in postnatal neovascularization. However, the interaction of these two pathways is not fully understood. The present study utilized CoCl(2) treated-endothelial progenitor cells (EPCs) (EPCs exposure to CoCl(2) are under mimic hypoxia) to examine the expressions of HIF-1alpha and HGF and futher to assess whether or not the inhibitor (2-methoxyestradiol [2ME2]) of HIF-1alpha decrease the HGF expression. In addition, to investigate the effects of HGF on the proliferation and tube formation of EPCs under mimic hypoxia, EPCs were transfected with NK4 (HGF antagonist) plasmid and exposed to CoCl(2), then the proliferation of these EPCs was assayed by MTS and the tube formation capacity of these EPCs on Matrigel was detected. The analysis indicated that CoCl(2) treatment induced HIF-1alpha expression of EPCs, and futher promoted HGF expression. While after 2ME2 was used in CoCl(2) treated-EPCs, HGF expression was markedly inhibited compared with non-pretreated EPCs with 2ME2, which also showed that HGF expression in EPCs was mediated by HIF-1alpha. Further, the results showed that after EPCs were transfected with NK4 in spite of being exposed to CoCl(2), their proliferation activity and tube formation capacity were weakened, which in turn indicated that HGF could promote the proliferation and the tube formation of EPCs, and this process might be regulated by HIF-1alpha. Twit Text FOAVip HGF expression induced by HIF-1alpha promote the proliferation and tube formation of endothelial progenitor cells ????Cell Biol Int http://www.kidney.de/pget.php?&tw=1&pmid=25339500 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25339500 #FOAvip English Wikipedia <ref>{{Cite pmid|25339500}}</ref> HGF expression induced by HIF-1alpha promote the proliferation and tube formation of endothelial progenitor cells #MMPMID25339500 Yu F; Lin Y; Zhan T; Chen L; Guo S Cell Biol Int 2015[Mar]; 39 (3): 310-7 PMID25339500show ga Hypoxia-inducible factor-1alpha (HIF-1alpha) and hepatocyte growth factor (HGF) play important roles in postnatal neovascularization. However, the interaction of these two pathways is not fully understood. The present study utilized CoCl(2) treated-endothelial progenitor cells (EPCs) (EPCs exposure to CoCl(2) are under mimic hypoxia) to examine the expressions of HIF-1alpha and HGF and futher to assess whether or not the inhibitor (2-methoxyestradiol [2ME2]) of HIF-1alpha decrease the HGF expression. In addition, to investigate the effects of HGF on the proliferation and tube formation of EPCs under mimic hypoxia, EPCs were transfected with NK4 (HGF antagonist) plasmid and exposed to CoCl(2), then the proliferation of these EPCs was assayed by MTS and the tube formation capacity of these EPCs on Matrigel was detected. The analysis indicated that CoCl(2) treatment induced HIF-1alpha expression of EPCs, and futher promoted HGF expression. While after 2ME2 was used in CoCl(2) treated-EPCs, HGF expression was markedly inhibited compared with non-pretreated EPCs with 2ME2, which also showed that HGF expression in EPCs was mediated by HIF-1alpha. Further, the results showed that after EPCs were transfected with NK4 in spite of being exposed to CoCl(2), their proliferation activity and tube formation capacity were weakened, which in turn indicated that HGF could promote the proliferation and the tube formation of EPCs, and this process might be regulated by HIF-1alpha. |2-Methoxyestradiol[MESH] |Animals[MESH] |Cell Culture Techniques[MESH] |Cell Hypoxia[MESH] |Cell Proliferation/drug effects[MESH] |Cells, Cultured[MESH] |Cobalt/pharmacology[MESH] |Collagen/chemistry[MESH] |Drug Combinations[MESH] |Endothelial Progenitor Cells/cytology/drug effects/metabolism[MESH] |Estradiol/analogs & derivatives/pharmacology[MESH] |Gene Expression/drug effects[MESH] |Hepatocyte Growth Factor/*metabolism[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors/*metabolism[MESH] |Laminin/chemistry[MESH] |Neovascularization, Pathologic/etiology[MESH] |Proteoglycans/chemistry[MESH] |Rats[MESH]HGF expression induced by HIF-1alpha promote the proliferation and tub(epmc).pdf DeepDyve Pubget Overpricing