Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/aas.12422 http://scihub22266oqcxt.onion/10.1111/aas.12422 25328143!4936904!25328143     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25328143&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Acta+Anaesthesiol+Scand 2015 ; 59 (2): 170-5 Nephropedia Template TP {{tp|p=25328143|t=2015. Osteopontin is associated with inflammation and mortality in a mouse model of polymicrobial sepsis |pdf=|usr=}}{{25328143}} gab.com Text Osteopontin is associated with inflammation and mortality in a mouse model of polymicrobial sepsis JO: Acta Anaesthesiol Scand http://www.kidney.de/pget.php?&tw=1&pmid=25328143 #FOAvip BACKGROUND: Osteopontin (OPN) is a multifunctional glycoprotein with pro-inflammatory properties. In severe sepsis, levels of plasma OPN are significantly higher in non-survivors than in survivors. We hypothesized that OPN results in greater inflammation and worse outcome through modulation of endogenous glucocorticoid production in sepsis. METHODS AND RESULTS: Sepsis was induced by cecal ligation and puncture (CLP) in wild type (WT) and OPN gene knockout (OPN(-/-) ) mice. In response to sepsis, the OPN(-/-) mice had lower levels of plasma cytokines and chemokines than the WT mice. The levels of corticosterone in plasma were similar between WT and OPN(-/-) sham animals but they increased 24 h after CLP induction in the WT mice, but not in the OPN(-/-) mice. The mortality rate was lower in the OPN(-/-) mice than in the WT mice. CONCLUSION: OPN is associated with greater inflammatory response and increased mortality, despite the higher corticosterone levels in plasma. Corticosterone production is not impaired in the absence of OPN. Twit Text FOAVip Osteopontin is associated with inflammation and mortality in a mouse model of polymicrobial sepsis ????Acta Anaesthesiol Scand http://www.kidney.de/pget.php?&tw=1&pmid=25328143 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25328143 #FOAvip English Wikipedia <ref>{{Cite pmid|25328143}}</ref> Osteopontin is associated with inflammation and mortality in a mouse model of polymicrobial sepsis #MMPMID25328143 Fortis S; Khadaroo RG; Haitsma JJ; Zhang H Acta Anaesthesiol Scand 2015[Feb]; 59 (2): 170-5 PMID25328143show ga BACKGROUND: Osteopontin (OPN) is a multifunctional glycoprotein with pro-inflammatory properties. In severe sepsis, levels of plasma OPN are significantly higher in non-survivors than in survivors. We hypothesized that OPN results in greater inflammation and worse outcome through modulation of endogenous glucocorticoid production in sepsis. METHODS AND RESULTS: Sepsis was induced by cecal ligation and puncture (CLP) in wild type (WT) and OPN gene knockout (OPN(-/-) ) mice. In response to sepsis, the OPN(-/-) mice had lower levels of plasma cytokines and chemokines than the WT mice. The levels of corticosterone in plasma were similar between WT and OPN(-/-) sham animals but they increased 24 h after CLP induction in the WT mice, but not in the OPN(-/-) mice. The mortality rate was lower in the OPN(-/-) mice than in the WT mice. CONCLUSION: OPN is associated with greater inflammatory response and increased mortality, despite the higher corticosterone levels in plasma. Corticosterone production is not impaired in the absence of OPN. |Animals[MESH] |Corticosterone/blood[MESH] |Cytokines/blood[MESH] |Disease Models, Animal[MESH] |Inflammation/*blood/*mortality[MESH] |Interleukin-6/blood[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Osteopontin/*blood[MESH] |Sepsis/*blood/*mortality[MESH]Osteopontin is associated with inflammation and mortality in a mouse m(epmc).pdf DeepDyve Pubget Overpricing