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10.1038/nri3743 http://scihub22266oqcxt.onion/10.1038/nri3743 25324125!ä!25324125 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Immunol 2014 ; 14 (11): 759-67 Nephropedia Template TP {{tp|p=25324125|t=2014. Regulated cell death and inflammation: an auto-amplification loop causes organ failure |pdf=|usr=}}{{25324125}} gab.com Text Regulated cell death and inflammation: an auto-amplification loop causes organ failure JO: Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25324125 #FOAvip Regulated cell death (RCD) is either immunologically silent or immunogenic. RCD in parenchymal cells may lead to the release of damage- associated molecular patterns that drive both tissue inflammation and the activation of further pathways of RCD. Following an initial event of regulated necrosis, RCD and inflammation can induce each other and drive a local auto-amplification loop that leads to exaggerated cell death and inflammation. In this Opinion article, we propose that such crosstalk between pro-inflammatory and RCD pathways has pathophysiological relevance in solid organ failure, transplantation and cancer. In our opinion, clinicians should not only prescribe immunosuppressive treatments to disrupt this circuit, but also implement the neglected therapeutic option of adding compounds that interfere with RCD. Twit Text FOAVip Regulated cell death and inflammation: an auto-amplification loop causes organ failure ????Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25324125 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25324125 #FOAvip English Wikipedia <ref>{{Cite pmid|25324125}}</ref> Regulated cell death and inflammation: an auto-amplification loop causes organ failure #MMPMID25324125 Linkermann A; Stockwell BR; Krautwald S; Anders HJ Nat Rev Immunol 2014[Nov]; 14 (11): 759-67 PMID25324125show ga Regulated cell death (RCD) is either immunologically silent or immunogenic. RCD in parenchymal cells may lead to the release of damage- associated molecular patterns that drive both tissue inflammation and the activation of further pathways of RCD. Following an initial event of regulated necrosis, RCD and inflammation can induce each other and drive a local auto-amplification loop that leads to exaggerated cell death and inflammation. In this Opinion article, we propose that such crosstalk between pro-inflammatory and RCD pathways has pathophysiological relevance in solid organ failure, transplantation and cancer. In our opinion, clinicians should not only prescribe immunosuppressive treatments to disrupt this circuit, but also implement the neglected therapeutic option of adding compounds that interfere with RCD. |Animals[MESH] |Apoptosis/*immunology[MESH] |Humans[MESH] |Immunosuppression Therapy[MESH] |Immunosuppressive Agents/therapeutic use[MESH] |Immunotherapy[MESH] |Inflammation/drug therapy/immunology[MESH] |Mice[MESH] |Mitochondria/immunology[MESH] |Multiple Organ Failure/*immunology/*therapy[MESH] |Necrosis/*immunology/therapy[MESH]Regulated cell death and inflammation: an auto-amplification loop caus(epmc).pdf DeepDyve Pubget Overpricing