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10.7243/2055-2394-1-1 http://scihub22266oqcxt.onion/10.7243/2055-2394-1-1 25309746!4193900!25309746     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25309746&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Immunother+Appl 2014 ; 1 (?): 1 Nephropedia Template TP {{tp|p=25309746|t=2014. Sex Differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE) |pdf=|usr=}}{{25309746}} gab.com Text Sex Differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE) JO: J Immunother Appl http://www.kidney.de/pget.php?&tw=1&pmid=25309746 #FOAvip It has been shown that TLR7 and TLR9 signaling play a role in SLE pathogenesis. Our recent study revealed that estrogen receptor alpha knockout mice have impaired inflammatory responses to TLR3, TLR4, TLR7 and TLR9 ligand stimulation in DCs, B cells and whole spleen cells. These findings indicate that estrogen receptor mediated signaling may impact universal TLR responsiveness. Whether estrogen has a direct or indirect effect on TLR responsiveness by immune cells is not clear. There is evidence of a role of TLR4 in SLE disease pathogenesis, such as the kidney damage, the induction of CD40 and autoantibodies, the suppression of regulatory T cells, and the role of pro-inflammatory cytokines (e.g., IL-6, IL-1beta, TNF-alpha) in SLE pathogenesis that can be induced by TLR4-mediated monocyte activation, suggesting that TLR4 and TLR4 responsiveness are also important for SLE disease. This review will focus on TLR4 responses and monocytes, which are understudied in systemic autoimmune diseases such as SLE. Twit Text FOAVip Sex Differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE) ????J Immunother Appl http://www.kidney.de/pget.php?&tw=1&pmid=25309746 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25309746 #FOAvip English Wikipedia <ref>{{Cite pmid|25309746}}</ref> Sex Differences in monocytes and TLR4 associated immune responses; implications for systemic lupus erythematosus (SLE) #MMPMID25309746 Jiang W; Gilkeson G J Immunother Appl 2014[Mar]; 1 (?): 1 PMID25309746show ga It has been shown that TLR7 and TLR9 signaling play a role in SLE pathogenesis. Our recent study revealed that estrogen receptor alpha knockout mice have impaired inflammatory responses to TLR3, TLR4, TLR7 and TLR9 ligand stimulation in DCs, B cells and whole spleen cells. These findings indicate that estrogen receptor mediated signaling may impact universal TLR responsiveness. Whether estrogen has a direct or indirect effect on TLR responsiveness by immune cells is not clear. There is evidence of a role of TLR4 in SLE disease pathogenesis, such as the kidney damage, the induction of CD40 and autoantibodies, the suppression of regulatory T cells, and the role of pro-inflammatory cytokines (e.g., IL-6, IL-1beta, TNF-alpha) in SLE pathogenesis that can be induced by TLR4-mediated monocyte activation, suggesting that TLR4 and TLR4 responsiveness are also important for SLE disease. This review will focus on TLR4 responses and monocytes, which are understudied in systemic autoimmune diseases such as SLE. ?Sex Differences in monocytes and TLR4 associated immune responses; imp(epmc).pdf DeepDyve Pubget Overpricing