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10.1016/j.canlet.2014.09.032

http://scihub22266oqcxt.onion/10.1016/j.canlet.2014.09.032
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25304381!ä!25304381

suck abstract from ncbi


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pmid25304381      Cancer+Lett 2015 ; 356 (2 Pt B): 483-90
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  • TRPM7 promotes the metastatic process in human nasopharyngeal carcinoma #MMPMID25304381
  • Chen JP; Wang J; Luan Y; Wang CX; Li WH; Zhang JB; Sha D; Shen R; Cui YG; Zhang Z; Zhang LM; Wang WB
  • Cancer Lett 2015[Jan]; 356 (2 Pt B): 483-90 PMID25304381show ga
  • Our study observed the relationship between transient receptor potential melastatin 7 (TRPM7) expression and the metastatic process of nasopharyngeal carcinoma (NPC). We found that TRPM7 was overexpressed in 102 out of 206 (49.5%) human NPC cases and was significantly associated with clinical stage and lymphatic and distant metastasis. The results suggested that TRPM7 promotes NPC cell migration and invasion in vitro. Further, TRPM7 was correlated with poor clinical outcome and was an independent predictor for 5-year overall survival rate (HR, 1.832; 95% CI, 1.237-4.146 [P = 0.041]). In conclusion, TRPM7 promotes the metastasis of NPC and may serve as a prognostic marker in NPC patients.
  • |*Cell Movement[MESH]
  • |Blotting, Western[MESH]
  • |Carcinoma[MESH]
  • |Cell Proliferation[MESH]
  • |Cells, Cultured[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoenzyme Techniques[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nasopharyngeal Carcinoma[MESH]
  • |Nasopharyngeal Neoplasms/genetics/metabolism/*secondary[MESH]
  • |Nasopharynx/*metabolism/pathology[MESH]
  • |Neoplasm Invasiveness[MESH]
  • |Neoplasm Metastasis[MESH]
  • |Neoplasm Staging[MESH]
  • |Prognosis[MESH]
  • |Protein Serine-Threonine Kinases[MESH]
  • |RNA, Messenger/genetics[MESH]
  • |RNA, Small Interfering/genetics[MESH]
  • |Real-Time Polymerase Chain Reaction[MESH]
  • |Reverse Transcriptase Polymerase Chain Reaction[MESH]
  • |Survival Rate[MESH]


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