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10.1016/j.brainres.2014.09.064 http://scihub22266oqcxt.onion/10.1016/j.brainres.2014.09.064 25289585/?report=reader!4385417!25289585     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25289585&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Brain+Res 2015 ; 1607 (ä): 47-74 Nephropedia Template TP {{tp|p=25289585|t=2015. A fruitful endeavor: modeling ALS in the fruit fly |pdf=|usr=}}{{25289585}} gab.com Text A fruitful endeavor: modeling ALS in the fruit fly JO: Brain Res http://www.kidney.de/pget.php?&tw=1&pmid=25289585 #FOAvip For over a century Drosophila melanogaster, commonly known as the fruit fly, has been instrumental in genetics research and disease modeling. In more recent years, it has been a powerful tool for modeling and studying neurodegenerative diseases, including the devastating and fatal amyotrophic lateral sclerosis (ALS). The success of this model organism in ALS research comes from the availability of tools to manipulate gene/protein expression in a number of desired cell-types, and the subsequent recapitulation of cellular and molecular phenotypic features of the disease. Several Drosophila models have now been developed for studying the roles of ALS-associated genes in disease pathogenesis that allowed us to understand the molecular pathways that lead to motor neuron degeneration in ALS patients. Our primary goal in this review is to highlight the lessons we have learned using Drosophila models pertaining to ALS research. This article is part of a Special Issue entitled ALS complex pathogenesis. Twit Text FOAVip A fruitful endeavor: modeling ALS in the fruit fly ????Brain Res http://www.kidney.de/pget.php?&tw=1&pmid=25289585 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25289585 #FOAvip English Wikipedia <ref>{{Cite pmid|25289585}}</ref> A fruitful endeavor: modeling ALS in the fruit fly #MMPMID25289585 Casci I; Pandey UB Brain Res 2015[May]; 1607 (ä): 47-74 PMID25289585show ga For over a century Drosophila melanogaster, commonly known as the fruit fly, has been instrumental in genetics research and disease modeling. In more recent years, it has been a powerful tool for modeling and studying neurodegenerative diseases, including the devastating and fatal amyotrophic lateral sclerosis (ALS). The success of this model organism in ALS research comes from the availability of tools to manipulate gene/protein expression in a number of desired cell-types, and the subsequent recapitulation of cellular and molecular phenotypic features of the disease. Several Drosophila models have now been developed for studying the roles of ALS-associated genes in disease pathogenesis that allowed us to understand the molecular pathways that lead to motor neuron degeneration in ALS patients. Our primary goal in this review is to highlight the lessons we have learned using Drosophila models pertaining to ALS research. This article is part of a Special Issue entitled ALS complex pathogenesis. |*Disease Models, Animal[MESH] |Amyotrophic Lateral Sclerosis/genetics/*physiopathology[MESH] |Animals[MESH] |Animals, Genetically Modified[MESH] |Drosophila melanogaster/genetics/*physiology[MESH]A fruitful endeavor: modeling ALS in the fruit fly (epmc).pdf DeepDyve Pubget Overpricing