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10.1097/CRD.0000000000000042

http://scihub22266oqcxt.onion/10.1097/CRD.0000000000000042
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25275717!ä!25275717

suck abstract from ncbi


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pmid25275717      Cardiol+Rev 2015 ; 23 (1): 33-51
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  • Pulmonary arterial hypertension: a review in pharmacotherapy #MMPMID25275717
  • Patel BB; Feng Y; Cheng-Lai A
  • Cardiol Rev 2015[Jan]; 23 (1): 33-51 PMID25275717show ga
  • Pulmonary arterial hypertension (PAH) is a progressive disease that remains incurable. The past 2 decades have witnessed many advances in PAH-directed therapies. More recently, 3 new oral agents have become available in the United States within the past 2 years. Treprostinil is now available in extended-release oral tablets. Macitentan is the third endothelin receptor antagonist approved for use, demonstrating benefits on morbidity and mortality among patients with PAH in an event-driven study. Riociguat is the first soluble guanylate cyclase stimulator that has been approved for use in the United States. This article reviews the clinical efficacy and safety of these 3 agents and the roles they play in the management of PAH. Additionally, we review the limitations of using surrogate markers such as change in 6-minute walk distance to assess disease progression.
  • |*Disease Progression[MESH]
  • |Antihypertensive Agents/*therapeutic use[MESH]
  • |Drug Therapy/*trends[MESH]
  • |Epoprostenol/analogs & derivatives/therapeutic use[MESH]
  • |Humans[MESH]
  • |Hypertension, Pulmonary/*drug therapy/*physiopathology[MESH]
  • |Pyrazoles/therapeutic use[MESH]
  • |Pyrimidines/therapeutic use[MESH]
  • |Sulfonamides/therapeutic use[MESH]
  • |Time Factors[MESH]
  • |Treatment Outcome[MESH]


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