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10.1586/14787210.2014.966082 http://scihub22266oqcxt.onion/10.1586/14787210.2014.966082 25269880!ä!25269880 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Expert+Rev+Anti+Infect+Ther 2014 ; 12 (11): 1337-43 Nephropedia Template TP {{tp|p=25269880|t=2014. Targeting eicosanoid pathways in the development of novel anti-influenza drugs |pdf=|usr=}}{{25269880}} gab.com Text Targeting eicosanoid pathways in the development of novel anti-influenza drugs JO: Expert Rev Anti Infect Ther http://www.kidney.de/pget.php?&tw=1&pmid=25269880 #FOAvip The constant new emergence of life-threatening human respiratory viral pathogens presents new challenges to clinicians who are left with no available therapeutic interventions. Highly pathogenic strains of influenza A virus (IAV) share an enhanced capacity to propagate to the lower airways and paralyze alveolar macrophage antiviral capacity in order to replicate efficiently and cause pathologic inflammation. Following a century of using NSAIDs for the management of influenza symptoms, a number of studies have interrogated their function in the host response to IAV infection. We herein provide an overview of these studies as well as further insight of how pathogenic IAV hijacks the microsomal prostaglandin E synthase-1-dependent prostaglandin E2 pathway in order to evade host type I interferon-mediated antiviral immunity. We also reflect on the potential beneficial action of microsomal prostaglandin E synthase-1 inhibitory compounds in the treatment of IAV infections and potentially other RNA viruses. Twit Text FOAVip Targeting eicosanoid pathways in the development of novel anti-influenza drugs ????Expert Rev Anti Infect Ther http://www.kidney.de/pget.php?&tw=1&pmid=25269880 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25269880 #FOAvip English Wikipedia <ref>{{Cite pmid|25269880}}</ref> Targeting eicosanoid pathways in the development of novel anti-influenza drugs #MMPMID25269880 Coulombe F; Divangahi M Expert Rev Anti Infect Ther 2014[Nov]; 12 (11): 1337-43 PMID25269880show ga The constant new emergence of life-threatening human respiratory viral pathogens presents new challenges to clinicians who are left with no available therapeutic interventions. Highly pathogenic strains of influenza A virus (IAV) share an enhanced capacity to propagate to the lower airways and paralyze alveolar macrophage antiviral capacity in order to replicate efficiently and cause pathologic inflammation. Following a century of using NSAIDs for the management of influenza symptoms, a number of studies have interrogated their function in the host response to IAV infection. We herein provide an overview of these studies as well as further insight of how pathogenic IAV hijacks the microsomal prostaglandin E synthase-1-dependent prostaglandin E2 pathway in order to evade host type I interferon-mediated antiviral immunity. We also reflect on the potential beneficial action of microsomal prostaglandin E synthase-1 inhibitory compounds in the treatment of IAV infections and potentially other RNA viruses. |*Eicosanoids[MESH] |Antiviral Agents/*therapeutic use[MESH] |Humans[MESH] |Influenza, Human/*drug therapy[MESH]Targeting eicosanoid pathways in the development of novel anti-influen(epmc).pdf DeepDyve Pubget Overpricing