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10.1007/82_2014_411 http://scihub22266oqcxt.onion/10.1007/82_2014_411 25267464!ä!25267464 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Top+Microbiol+Immunol 2015 ; 386 (ä): 3-22 Nephropedia Template TP {{tp|p=25267464|t=2015. The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options |pdf=|usr=}}{{25267464}} gab.com Text The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options JO: Curr Top Microbiol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25267464 #FOAvip Aberrant pulmonary immune responses are linked to the pathogenesis of multiple human respiratory viral infections. Elevated cytokine and chemokine production "cytokine storm" has been continuously associated with poor clinical outcome and pathogenesis during influenza virus infection in humans and animal models. Initial trials using global immune suppression with corticosteroids or targeted neutralization of single inflammatory mediators proved ineffective to ameliorate pathology during pathogenic influenza virus infection. Thus, it was believed that cytokine storm was either chemically intractable or not causal in the pathology observed. During this review, we will discuss the history of research assessing the roles various cytokines, chemokines, and innate immune cells play in promoting pathology or protection during influenza virus infection. Several promising new strategies modulating lipid signaling have been recently uncovered for global blunting, but not ablation, of innate immune responses following influenza virus infection. Importantly, modulating lipid signaling through various means has proven effective at curbing morbidity and mortality in animal models and may be useful for curbing influenza virus induced pathology in humans. Finally, we highlight future research directions for mechanistically dissecting how modulation of lipid signaling pathways results in favorable outcomes following influenza virus infection. Twit Text FOAVip The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options ????Curr Top Microbiol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25267464 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25267464 #FOAvip English Wikipedia <ref>{{Cite pmid|25267464}}</ref> The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options #MMPMID25267464 Teijaro JR Curr Top Microbiol Immunol 2015[]; 386 (ä): 3-22 PMID25267464show ga Aberrant pulmonary immune responses are linked to the pathogenesis of multiple human respiratory viral infections. Elevated cytokine and chemokine production "cytokine storm" has been continuously associated with poor clinical outcome and pathogenesis during influenza virus infection in humans and animal models. Initial trials using global immune suppression with corticosteroids or targeted neutralization of single inflammatory mediators proved ineffective to ameliorate pathology during pathogenic influenza virus infection. Thus, it was believed that cytokine storm was either chemically intractable or not causal in the pathology observed. During this review, we will discuss the history of research assessing the roles various cytokines, chemokines, and innate immune cells play in promoting pathology or protection during influenza virus infection. Several promising new strategies modulating lipid signaling have been recently uncovered for global blunting, but not ablation, of innate immune responses following influenza virus infection. Importantly, modulating lipid signaling through various means has proven effective at curbing morbidity and mortality in animal models and may be useful for curbing influenza virus induced pathology in humans. Finally, we highlight future research directions for mechanistically dissecting how modulation of lipid signaling pathways results in favorable outcomes following influenza virus infection. |Animals[MESH] |Cytokines/*physiology[MESH] |Dendritic Cells/immunology[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Influenza, Human/drug therapy/etiology/*immunology[MESH] |Macrophages/immunology[MESH]The role of cytokine responses during influenza virus pathogenesis and(epmc).pdf DeepDyve Pubget Overpricing