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Potential interplay between NFkappaB and PPARgamma in human dermal microvascular endothelial cells cultured in low magnesium #MMPMID25245457
Castiglioni S; Cazzaniga A; Maier JA
Magnes Res 2014[Apr]; 27 (2): 86-93 PMID25245457show ga
Dermal microvascular endothelial cells contribute to cutaneous inflammation by secreting proinflammatory cytokines and chemokines. We show here that low extracellular magnesium stimulates the secretion of interleukin 8 and monocyte chemoattractant protein-1 in dermal microvascular endothelial cells. This secretory pattern might result from interplay between NFkappaB, the master regulator of inflammation, and PPARgamma, a transcription factor that has emerged as an inhibitor of inflammation. Indeed, both NFkappaB and PPARgamma are activated in dermal microvascular endothelial cells cultured in low magnesium-containing medium. In conclusion, we hypothesize that PPARgamma and NFkappaB might contribute to the response of these cells to low Mg.