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10.1684/mrh.2014.0365

http://scihub22266oqcxt.onion/10.1684/mrh.2014.0365
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25245457!ä!25245457

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suck abstract from ncbi


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pmid25245457      Magnes+Res 2014 ; 27 (2): 86-93
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  • Potential interplay between NFkappaB and PPARgamma in human dermal microvascular endothelial cells cultured in low magnesium #MMPMID25245457
  • Castiglioni S; Cazzaniga A; Maier JA
  • Magnes Res 2014[Apr]; 27 (2): 86-93 PMID25245457show ga
  • Dermal microvascular endothelial cells contribute to cutaneous inflammation by secreting proinflammatory cytokines and chemokines. We show here that low extracellular magnesium stimulates the secretion of interleukin 8 and monocyte chemoattractant protein-1 in dermal microvascular endothelial cells. This secretory pattern might result from interplay between NFkappaB, the master regulator of inflammation, and PPARgamma, a transcription factor that has emerged as an inhibitor of inflammation. Indeed, both NFkappaB and PPARgamma are activated in dermal microvascular endothelial cells cultured in low magnesium-containing medium. In conclusion, we hypothesize that PPARgamma and NFkappaB might contribute to the response of these cells to low Mg.
  • |Cells, Cultured[MESH]
  • |Dermis/cytology/drug effects/*metabolism[MESH]
  • |Endothelial Cells/drug effects/*metabolism[MESH]
  • |Humans[MESH]
  • |Magnesium/*administration & dosage[MESH]
  • |Microcirculation/drug effects/*physiology[MESH]
  • |NF-kappa B/*metabolism[MESH]


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