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Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Adv+Exp+Med+Biol 2014 ; 825 (ä): 1-55 Nephropedia Template TP
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Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease #MMPMID25201102
Gerstberger S; Hafner M; Ascano M; Tuschl T
Adv Exp Med Biol 2014[]; 825 (ä): 1-55 PMID25201102show ga
RNA-binding proteins (RBPs) are effectors and regulators of posttranscriptional gene regulation (PTGR). RBPs regulate stability, maturation, and turnover of all RNAs, often binding thousands of targets at many sites. The importance of RBPs is underscored by their dysregulation or mutations causing a variety of developmental and neurological diseases. This chapter globally discusses human RBPs and provides a brief introduction to their identification and RNA targets. We review RBPs based on common structural RNA-binding domains, study their evolutionary conservation and expression, and summarize disease associations of different RBP classes.