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10.1007/978-1-4939-1221-6_1

http://scihub22266oqcxt.onion/10.1007/978-1-4939-1221-6_1
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suck abstract from ncbi


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pmid25201102      Adv+Exp+Med+Biol 2014 ; 825 (ä): 1-55
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  • Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease #MMPMID25201102
  • Gerstberger S; Hafner M; Ascano M; Tuschl T
  • Adv Exp Med Biol 2014[]; 825 (ä): 1-55 PMID25201102show ga
  • RNA-binding proteins (RBPs) are effectors and regulators of posttranscriptional gene regulation (PTGR). RBPs regulate stability, maturation, and turnover of all RNAs, often binding thousands of targets at many sites. The importance of RBPs is underscored by their dysregulation or mutations causing a variety of developmental and neurological diseases. This chapter globally discusses human RBPs and provides a brief introduction to their identification and RNA targets. We review RBPs based on common structural RNA-binding domains, study their evolutionary conservation and expression, and summarize disease associations of different RBP classes.
  • |*Evolution, Molecular[MESH]
  • |Gene Expression Regulation/*physiology[MESH]
  • |Genetic Diseases, Inborn/*genetics/*metabolism[MESH]
  • |Humans[MESH]
  • |Mutation[MESH]


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