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10.1161/STROKEAHA.114.006617 http://scihub22266oqcxt.onion/10.1161/STROKEAHA.114.006617 25190438!ä!25190438 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stroke 2014 ; 45 (10): 3092-6 Nephropedia Template TP {{tp|p=25190438|t=2014. Impaired glymphatic perfusion after strokes revealed by contrast-enhanced MRI: a new target for fibrinolysis?|pdf=|usr=}}{{25190438}} gab.com Text Impaired glymphatic perfusion after strokes revealed by contrast-enhanced MRI: a new target for fibrinolysis JO: Stroke http://www.kidney.de/pget.php?&tw=1&pmid=25190438 #FOAvip BACKGROUND AND PURPOSE: The aim of the present study was to investigate the impact of different stroke subtypes on the glymphatic system using MRI. METHODS: We first improved and characterized an in vivo protocol to measure the perfusion of the glymphatic system using MRI after minimally invasive injection of a gadolinium chelate within the cisterna magna. Then, the integrity of the glymphatic system was evaluated in 4 stroke models in mice including subarachnoid hemorrhage (SAH), intracerebral hemorrhage, carotid ligature, and embolic ischemic stroke. RESULTS: We were able to reliably evaluate the glymphatic system function using MRI. Moreover, we provided evidence that the glymphatic system was severely impaired after SAH and in the acute phase of ischemic stroke, but was not altered after carotid ligature or in case of intracerebral hemorrhage. Notably, this alteration in glymphatic perfusion reduced brain clearance rate of low-molecular-weight compounds. Interestingly, glymphatic perfusion after SAH can be improved by intracerebroventricular injection of tissue-type plasminogen activator. Moreover, spontaneous arterial recanalization was associated with restoration of the glymphatic function after embolic ischemic stroke. CONCLUSIONS: SAH and acute ischemic stroke significantly impair the glymphatic system perfusion. In these contexts, injection of tissue-type plasminogen activator either intracerebroventricularly to clear perivascular spaces (for SAH) or intravenously to restore arterial patency (for ischemic stroke) may improve glymphatic function. Twit Text FOAVip Impaired glymphatic perfusion after strokes revealed by contrast-enhanced MRI: a new target for fibrinolysis ????Stroke http://www.kidney.de/pget.php?&tw=1&pmid=25190438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25190438 #FOAvip English Wikipedia <ref>{{Cite pmid|25190438}}</ref> Impaired glymphatic perfusion after strokes revealed by contrast-enhanced MRI: a new target for fibrinolysis? #MMPMID25190438 Gaberel T; Gakuba C; Goulay R; Martinez De Lizarrondo S; Hanouz JL; Emery E; Touze E; Vivien D; Gauberti M Stroke 2014[Oct]; 45 (10): 3092-6 PMID25190438show ga BACKGROUND AND PURPOSE: The aim of the present study was to investigate the impact of different stroke subtypes on the glymphatic system using MRI. METHODS: We first improved and characterized an in vivo protocol to measure the perfusion of the glymphatic system using MRI after minimally invasive injection of a gadolinium chelate within the cisterna magna. Then, the integrity of the glymphatic system was evaluated in 4 stroke models in mice including subarachnoid hemorrhage (SAH), intracerebral hemorrhage, carotid ligature, and embolic ischemic stroke. RESULTS: We were able to reliably evaluate the glymphatic system function using MRI. Moreover, we provided evidence that the glymphatic system was severely impaired after SAH and in the acute phase of ischemic stroke, but was not altered after carotid ligature or in case of intracerebral hemorrhage. Notably, this alteration in glymphatic perfusion reduced brain clearance rate of low-molecular-weight compounds. Interestingly, glymphatic perfusion after SAH can be improved by intracerebroventricular injection of tissue-type plasminogen activator. Moreover, spontaneous arterial recanalization was associated with restoration of the glymphatic function after embolic ischemic stroke. CONCLUSIONS: SAH and acute ischemic stroke significantly impair the glymphatic system perfusion. In these contexts, injection of tissue-type plasminogen activator either intracerebroventricularly to clear perivascular spaces (for SAH) or intravenously to restore arterial patency (for ischemic stroke) may improve glymphatic function. |Animals[MESH] |Cerebrospinal Fluid/physiology[MESH] |Contrast Media[MESH] |Disease Models, Animal[MESH] |Image Interpretation, Computer-Assisted[MESH] |Magnetic Resonance Imaging/*methods[MESH] |Mice[MESH] |Stroke/*cerebrospinal fluid/pathology[MESH]Impaired glymphatic perfusion after strokes revealed by contrast-enhan(epmc).pdf DeepDyve Pubget Overpricing