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10.3390/toxins6082483 http://scihub22266oqcxt.onion/10.3390/toxins6082483 25153255!4147595!25153255     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxins+(Basel) 2014 ; 6 (8): 2483-540 Nephropedia Template TP {{tp|p=25153255|t=2014. Channel-forming bacterial toxins in biosensing and macromolecule delivery |pdf=|usr=}}{{25153255}} gab.com Text Channel-forming bacterial toxins in biosensing and macromolecule delivery JO: Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=25153255 #FOAvip To intoxicate cells, pore-forming bacterial toxins are evolved to allow for the transmembrane traffic of different substrates, ranging from small inorganic ions to cell-specific polypeptides. Recent developments in single-channel electrical recordings, X-ray crystallography, protein engineering, and computational methods have generated a large body of knowledge about the basic principles of channel-mediated molecular transport. These discoveries provide a robust framework for expansion of the described principles and methods toward use of biological nanopores in the growing field of nanobiotechnology. This article, written for a special volume on "Intracellular Traffic and Transport of Bacterial Protein Toxins", reviews the current state of applications of pore-forming bacterial toxins in small- and macromolecule-sensing, targeted cancer therapy, and drug delivery. We discuss the electrophysiological studies that explore molecular details of channel-facilitated protein and polymer transport across cellular membranes using both natural and foreign substrates. The review focuses on the structurally and functionally different bacterial toxins: gramicidin A of Bacillus brevis, alpha-hemolysin of Staphylococcus aureus, and binary toxin of Bacillus anthracis, which have found their "second life" in a variety of developing medical and technological applications. Twit Text FOAVip Channel-forming bacterial toxins in biosensing and macromolecule delivery ????Toxins (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=25153255 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25153255 #FOAvip English Wikipedia <ref>{{Cite pmid|25153255}}</ref> Channel-forming bacterial toxins in biosensing and macromolecule delivery #MMPMID25153255 Gurnev PA; Nestorovich EM Toxins (Basel) 2014[Aug]; 6 (8): 2483-540 PMID25153255show ga To intoxicate cells, pore-forming bacterial toxins are evolved to allow for the transmembrane traffic of different substrates, ranging from small inorganic ions to cell-specific polypeptides. Recent developments in single-channel electrical recordings, X-ray crystallography, protein engineering, and computational methods have generated a large body of knowledge about the basic principles of channel-mediated molecular transport. These discoveries provide a robust framework for expansion of the described principles and methods toward use of biological nanopores in the growing field of nanobiotechnology. This article, written for a special volume on "Intracellular Traffic and Transport of Bacterial Protein Toxins", reviews the current state of applications of pore-forming bacterial toxins in small- and macromolecule-sensing, targeted cancer therapy, and drug delivery. We discuss the electrophysiological studies that explore molecular details of channel-facilitated protein and polymer transport across cellular membranes using both natural and foreign substrates. The review focuses on the structurally and functionally different bacterial toxins: gramicidin A of Bacillus brevis, alpha-hemolysin of Staphylococcus aureus, and binary toxin of Bacillus anthracis, which have found their "second life" in a variety of developing medical and technological applications. |*Bacterial Proteins/metabolism/therapeutic use[MESH] |*Bacterial Toxins/metabolism/therapeutic use[MESH] |*Pore Forming Cytotoxic Proteins/metabolism/therapeutic use[MESH] |Animals[MESH] |Biological Transport[MESH] |Biosensing Techniques[MESH] |Drug Delivery Systems[MESH] |Humans[MESH]Channel-forming bacterial toxins in biosensing and macromolecule deliv(epmc).pdf DeepDyve Pubget Overpricing