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Proton-pump inhibitor use is associated with lower urinary magnesium excretion #MMPMID25142949
William JH; Nelson R; Hayman N; Mukamal KJ; Danziger J
Nephrology (Carlton) 2014[Dec]; 19 (12): 798-801 PMID25142949show ga
AIMS: Although multiple recent studies have confirmed an association between chronic proton-pump inhibitor (PPI) use and hypomagnesaemia, the physiologic explanation for this association remains uncertain. To address this, we investigated the association of PPI use with urinary magnesium excretion. METHODS: We measured 24-hour urine magnesium excretion in collections performed for nephrolithiasis evaluation in 278 consecutive ambulatory patients and determined PPI use from contemporaneous medical records. RESULTS: There were 50 (18%) PPI users at the time of urine collection. The mean daily urinary magnesium was 84.6 +/- 42.8 mg in PPI users, compared with 101.2 +/- 41.1 mg in non-PPI users (P = 0.01). In adjusted analyses, PPI use was associated with 10.54 +/- 5.30 mg/day lower daily urinary magnesium excretion (P = 0.05). Diuretic use did not significantly modify the effect of PPI on urinary magnesium. As a control, PPI use was not associated with other urinary indicators of nutritional intake. CONCLUSIONS: Our findings suggest that PPI use is associated with lower 24-hour urine magnesium excretion. Whether this reflects decreased intestinal uptake due to PPI exposure, or residual confounding due to decreased magnesium intake, requires further study.
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Nephrology+(Carlton) 2014 ; 19 (12): 798-801
