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10.1111/nep.12330 http://scihub22266oqcxt.onion/10.1111/nep.12330 25142949!4313878!25142949     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nephrology+(Carlton) 2014 ; 19 (12): 798-801 Nephropedia Template TP {{tp|p=25142949|t=2014. Proton-pump inhibitor use is associated with lower urinary magnesium excretion |pdf=|usr=}}{{25142949}} gab.com Text Proton-pump inhibitor use is associated with lower urinary magnesium excretion JO: Nephrology (Carlton) http://www.kidney.de/pget.php?&tw=1&pmid=25142949 #FOAvip AIMS: Although multiple recent studies have confirmed an association between chronic proton-pump inhibitor (PPI) use and hypomagnesaemia, the physiologic explanation for this association remains uncertain. To address this, we investigated the association of PPI use with urinary magnesium excretion. METHODS: We measured 24-hour urine magnesium excretion in collections performed for nephrolithiasis evaluation in 278 consecutive ambulatory patients and determined PPI use from contemporaneous medical records. RESULTS: There were 50 (18%) PPI users at the time of urine collection. The mean daily urinary magnesium was 84.6 +/- 42.8 mg in PPI users, compared with 101.2 +/- 41.1 mg in non-PPI users (P = 0.01). In adjusted analyses, PPI use was associated with 10.54 +/- 5.30 mg/day lower daily urinary magnesium excretion (P = 0.05). Diuretic use did not significantly modify the effect of PPI on urinary magnesium. As a control, PPI use was not associated with other urinary indicators of nutritional intake. CONCLUSIONS: Our findings suggest that PPI use is associated with lower 24-hour urine magnesium excretion. Whether this reflects decreased intestinal uptake due to PPI exposure, or residual confounding due to decreased magnesium intake, requires further study. Twit Text FOAVip Proton-pump inhibitor use is associated with lower urinary magnesium excretion ????Nephrology (Carlton) http://www.kidney.de/pget.php?&tw=1&pmid=25142949 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25142949 #FOAvip English Wikipedia <ref>{{Cite pmid|25142949}}</ref> Proton-pump inhibitor use is associated with lower urinary magnesium excretion #MMPMID25142949 William JH; Nelson R; Hayman N; Mukamal KJ; Danziger J Nephrology (Carlton) 2014[Dec]; 19 (12): 798-801 PMID25142949show ga AIMS: Although multiple recent studies have confirmed an association between chronic proton-pump inhibitor (PPI) use and hypomagnesaemia, the physiologic explanation for this association remains uncertain. To address this, we investigated the association of PPI use with urinary magnesium excretion. METHODS: We measured 24-hour urine magnesium excretion in collections performed for nephrolithiasis evaluation in 278 consecutive ambulatory patients and determined PPI use from contemporaneous medical records. RESULTS: There were 50 (18%) PPI users at the time of urine collection. The mean daily urinary magnesium was 84.6 +/- 42.8 mg in PPI users, compared with 101.2 +/- 41.1 mg in non-PPI users (P = 0.01). In adjusted analyses, PPI use was associated with 10.54 +/- 5.30 mg/day lower daily urinary magnesium excretion (P = 0.05). Diuretic use did not significantly modify the effect of PPI on urinary magnesium. As a control, PPI use was not associated with other urinary indicators of nutritional intake. CONCLUSIONS: Our findings suggest that PPI use is associated with lower 24-hour urine magnesium excretion. Whether this reflects decreased intestinal uptake due to PPI exposure, or residual confounding due to decreased magnesium intake, requires further study. |Adult[MESH] |Aged[MESH] |Biomarkers/urine[MESH] |Boston[MESH] |Down-Regulation[MESH] |Female[MESH] |Humans[MESH] |Kidney/*drug effects/metabolism[MESH] |Magnesium/*urine[MESH] |Male[MESH] |Middle Aged[MESH] |Proton Pump Inhibitors/*adverse effects[MESH]Proton-pump inhibitor use is associated with lower urinary magnesium e(epmc).pdf DeepDyve Pubget Overpricing