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10.1371/journal.pone.0105096 http://scihub22266oqcxt.onion/10.1371/journal.pone.0105096 25133393!4136864!25133393     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2014 ; 9 (8): e105096 Nephropedia Template TP {{tp|p=25133393|t=2014. MiR-152 may silence translation of CaMK II and induce spontaneous immune tolerance in mouse liver transplantation |pdf=|usr=}}{{25133393}} gab.com Text MiR-152 may silence translation of CaMK II and induce spontaneous immune tolerance in mouse liver transplantation JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25133393 #FOAvip Spontaneous immune tolerance in mouse liver transplantation has always been a hotspot in transplantation-immune research. Recent studies revealed that regulatory T cells (Tregs), hepatic satellite cells and Kupffer cells play a potential role in spontaneous immune tolerance, however the precise mechanism of spontaneous immune tolerance is still undefined. By using Microarray Chips, we investigated different immune regulatory factors to decipher critical mechanisms of spontaneous tolerance after mouse liver transplantation. Allogeneic (C57BL/6-C3H) and syngeneic (C3H-C3H) liver transplantation were performed by 6-8 weeks old male C57BL/6 and C3H mice. Graft samples (N = 4 each group) were collected from 8 weeks post-operation mice. 11 differentially expressed miRNAs in allogeneic grafts (Allografts) vs. syngeneic grafts (Syngrafts) were identified using Agilent Mouse miRNA Chips. It was revealed that 185 genes were modified by the 11 miRNAs, furthermore, within the 185 target genes, 11 of them were tightly correlated with immune regulation after Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis and Genbank data cross-comparison. Verified by real-time PCR and western blot, our results indicated that mRNA expression levels of IL-6 and TAB2 were respectively down regulated following miR-142-3p and miR-155 augment. In addition, increased miR-152 just silenced mRNA of CaMK II and down-regulated translation of CaMK II in tolerated liver grafts, which may play a critical role in immune regulation and spontaneous tolerance induction of mouse liver transplantation. Twit Text FOAVip MiR-152 may silence translation of CaMK II and induce spontaneous immune tolerance in mouse liver transplantation ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25133393 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25133393 #FOAvip English Wikipedia <ref>{{Cite pmid|25133393}}</ref> MiR-152 may silence translation of CaMK II and induce spontaneous immune tolerance in mouse liver transplantation #MMPMID25133393 Wang Y; Tian Y; Ding Y; Wang J; Yan S; Zhou L; Xie H; Chen H; Li H; Zhang J; Zhao J; Zheng S PLoS One 2014[]; 9 (8): e105096 PMID25133393show ga Spontaneous immune tolerance in mouse liver transplantation has always been a hotspot in transplantation-immune research. Recent studies revealed that regulatory T cells (Tregs), hepatic satellite cells and Kupffer cells play a potential role in spontaneous immune tolerance, however the precise mechanism of spontaneous immune tolerance is still undefined. By using Microarray Chips, we investigated different immune regulatory factors to decipher critical mechanisms of spontaneous tolerance after mouse liver transplantation. Allogeneic (C57BL/6-C3H) and syngeneic (C3H-C3H) liver transplantation were performed by 6-8 weeks old male C57BL/6 and C3H mice. Graft samples (N = 4 each group) were collected from 8 weeks post-operation mice. 11 differentially expressed miRNAs in allogeneic grafts (Allografts) vs. syngeneic grafts (Syngrafts) were identified using Agilent Mouse miRNA Chips. It was revealed that 185 genes were modified by the 11 miRNAs, furthermore, within the 185 target genes, 11 of them were tightly correlated with immune regulation after Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis and Genbank data cross-comparison. Verified by real-time PCR and western blot, our results indicated that mRNA expression levels of IL-6 and TAB2 were respectively down regulated following miR-142-3p and miR-155 augment. In addition, increased miR-152 just silenced mRNA of CaMK II and down-regulated translation of CaMK II in tolerated liver grafts, which may play a critical role in immune regulation and spontaneous tolerance induction of mouse liver transplantation. |*Liver Transplantation[MESH] |Animals[MESH] |Blotting, Western[MESH] |Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics/*metabolism[MESH] |Immune Tolerance/genetics/*immunology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |MicroRNAs/genetics/*physiology[MESH] |Oligonucleotide Array Sequence Analysis[MESH]MiR-152 may silence translation of CaMK II and induce spontaneous immu(epmc).pdf DeepDyve Pubget Overpricing