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10.1111/cmi.12339 http://scihub22266oqcxt.onion/10.1111/cmi.12339 25131332!7162390!25131332     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Microbiol 2015 ; 17 (1): 105-18 Nephropedia Template TP {{tp|p=25131332|t=2015. IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection |pdf=|usr=}}{{25131332}} gab.com Text IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection JO: Cell Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=25131332 #FOAvip Interferon-inducible transmembrane proteins 1, 2 and 3 (IFITM1, IFITM2 and IFITM3) have recently been identified as potent antiviral effectors that function to suppress the entry of a broad range of enveloped viruses and modulate cellular tropism independent of viral receptor expression. However, the antiviral effect and mechanisms of IFITMs in response to viral infections remain incompletely understood and characterized. In this work, we focused our investigation on the function of the extracellular IFITM3 protein. In cell models of DENV-2 infection, we found that IFITM3 contributed to both the baseline and interferon-induced inhibition of DENV entry. Most importantly, our study for the first time demonstrated the presence of IFITM-containing exosome in the extracellular environment, and identified an ability of cellular exosome to intercellularly deliver IFITM3 and thus transmit its antiviral effect from infected to non-infected cells. Thus, our findings provide new insights in the basic mechanisms underlying the actions of IFITM3, which might lead to future development of exosome-mediated anti-viral strategies using IFITM3 as a therapeutic agent. Conceivably, variations in the basal and inducible levels of IFITMs, as well as in intracellular and extracellular levels of IFITMs, might predict the severity of dengue virus infections among individuals or across species. Twit Text FOAVip IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection ????Cell Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=25131332 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25131332 #FOAvip English Wikipedia <ref>{{Cite pmid|25131332}}</ref> IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection #MMPMID25131332 Zhu X; He Z; Yuan J; Wen W; Huang X; Hu Y; Lin C; Pan J; Li R; Deng H; Liao S; Zhou R; Wu J; Li J; Li M Cell Microbiol 2015[Jan]; 17 (1): 105-18 PMID25131332show ga Interferon-inducible transmembrane proteins 1, 2 and 3 (IFITM1, IFITM2 and IFITM3) have recently been identified as potent antiviral effectors that function to suppress the entry of a broad range of enveloped viruses and modulate cellular tropism independent of viral receptor expression. However, the antiviral effect and mechanisms of IFITMs in response to viral infections remain incompletely understood and characterized. In this work, we focused our investigation on the function of the extracellular IFITM3 protein. In cell models of DENV-2 infection, we found that IFITM3 contributed to both the baseline and interferon-induced inhibition of DENV entry. Most importantly, our study for the first time demonstrated the presence of IFITM-containing exosome in the extracellular environment, and identified an ability of cellular exosome to intercellularly deliver IFITM3 and thus transmit its antiviral effect from infected to non-infected cells. Thus, our findings provide new insights in the basic mechanisms underlying the actions of IFITM3, which might lead to future development of exosome-mediated anti-viral strategies using IFITM3 as a therapeutic agent. Conceivably, variations in the basal and inducible levels of IFITMs, as well as in intracellular and extracellular levels of IFITMs, might predict the severity of dengue virus infections among individuals or across species. |Antiviral Agents/*metabolism[MESH] |Dengue Virus/*immunology/physiology[MESH] |Dengue/*immunology[MESH] |Exosomes/*metabolism[MESH] |Membrane Proteins/*metabolism[MESH] |RNA-Binding Proteins/*metabolism[MESH]IFITM3-containing exosome as a novel mediator for anti-viral response (epmc).pdf DeepDyve Pubget Overpricing