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10.1002/chem.201403560 http://scihub22266oqcxt.onion/10.1002/chem.201403560 25082061!7162048!25082061     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chemistry 2014 ; 20 (37): 11685-9 Nephropedia Template TP {{tp|p=25082061|t=2014. Synthesis and antiviral properties of spirocyclic 1,2,3 -triazolooxazine nucleosides |pdf=|usr=}}{{25082061}} gab.com Text Synthesis and antiviral properties of spirocyclic 1,2,3 -triazolooxazine nucleosides JO: Chemistry http://www.kidney.de/pget.php?&tw=1&pmid=25082061 #FOAvip An efficient synthesis of spirocyclic triazolooxazine nucleosides is described. This was achieved by the conversion of beta-D-psicofuranose to the corresponding azido-derivative, followed by alkylation of the primary alcohol with a range of propargyl bromides, obtained by Sonogashira chemistry. The products of these reactions underwent 1,3-dipolar addition smoothly to generate the protected spirocyclic adducts. These were easily deprotected to give the corresponding ribose nucleosides. The library of compounds obtained was investigated for its antiviral activity using MHV (mouse hepatitis virus) as a model wherein derivative 3 f showed the most promising activity and tolerability. Twit Text FOAVip Synthesis and antiviral properties of spirocyclic 1,2,3 -triazolooxazine nucleosides ????Chemistry http://www.kidney.de/pget.php?&tw=1&pmid=25082061 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25082061 #FOAvip English Wikipedia <ref>{{Cite pmid|25082061}}</ref> Synthesis and antiviral properties of spirocyclic 1,2,3 -triazolooxazine nucleosides #MMPMID25082061 Dell'Isola A; McLachlan MM; Neuman BW; Al-Mullah HM; Binks AW; Elvidge W; Shankland K; Cobb AJ Chemistry 2014[Sep]; 20 (37): 11685-9 PMID25082061show ga An efficient synthesis of spirocyclic triazolooxazine nucleosides is described. This was achieved by the conversion of beta-D-psicofuranose to the corresponding azido-derivative, followed by alkylation of the primary alcohol with a range of propargyl bromides, obtained by Sonogashira chemistry. The products of these reactions underwent 1,3-dipolar addition smoothly to generate the protected spirocyclic adducts. These were easily deprotected to give the corresponding ribose nucleosides. The library of compounds obtained was investigated for its antiviral activity using MHV (mouse hepatitis virus) as a model wherein derivative 3 f showed the most promising activity and tolerability. äSynthesis and antiviral properties of spirocyclic 1,2,3 -triazolooxaz(epmc).pdf DeepDyve Pubget Overpricing