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10.1016/j.ejcb.2014.07.001 http://scihub22266oqcxt.onion/10.1016/j.ejcb.2014.07.001 25073440!?!25073440 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25073440&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Eur+J+Cell+Biol 2014 ; 93 (10-12): 455-65 Nephropedia Template TP {{tp|p=25073440|t=2014. Function and regulation of the channel-kinase TRPM7 in health and disease |pdf=|usr=}}{{25073440}} gab.com Text Function and regulation of the channel-kinase TRPM7 in health and disease JO: Eur J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25073440 #FOAvip Transient receptor potential (TRP) cation channels represent a large and diverse family of ion channels that act as important transducers of sensory information. The Melastatin subfamily member TRPM7 has garnered much interest due to its functional kinase domain; a unique feature among ion channels. TRPM7 primarily conducts Ca(2+) and Mg(2+) and its activity is regulated by intracellular Mg(2+), phospholipase C-mediated signaling and mechanical cues. A growing number of studies emphasize a regulatory role for TRPM7 in proliferation and cell survival as well as cytoskeletal reorganization during adhesion and migration. Knockout approaches in animal models have revealed that TRPM7 significantly contributes to embryonic development and organogenesis. In addition, a role for TRPM7 to the pathophysiology of several diseases has become evident in recent years. Here, we discuss how recent insights have contributed to our understanding of TRPM7 function and regulation in health and disease. Twit Text FOAVip Function and regulation of the channel-kinase TRPM7 in health and disease ????Eur J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25073440 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25073440 #FOAvip English Wikipedia <ref>{{Cite pmid|25073440}}</ref> Function and regulation of the channel-kinase TRPM7 in health and disease #MMPMID25073440 Visser D; Middelbeek J; van Leeuwen FN; Jalink K Eur J Cell Biol 2014[Oct]; 93 (10-12): 455-65 PMID25073440show ga Transient receptor potential (TRP) cation channels represent a large and diverse family of ion channels that act as important transducers of sensory information. The Melastatin subfamily member TRPM7 has garnered much interest due to its functional kinase domain; a unique feature among ion channels. TRPM7 primarily conducts Ca(2+) and Mg(2+) and its activity is regulated by intracellular Mg(2+), phospholipase C-mediated signaling and mechanical cues. A growing number of studies emphasize a regulatory role for TRPM7 in proliferation and cell survival as well as cytoskeletal reorganization during adhesion and migration. Knockout approaches in animal models have revealed that TRPM7 significantly contributes to embryonic development and organogenesis. In addition, a role for TRPM7 to the pathophysiology of several diseases has become evident in recent years. Here, we discuss how recent insights have contributed to our understanding of TRPM7 function and regulation in health and disease. |Animals[MESH] |Cardiovascular Diseases/metabolism/pathology[MESH] |Cell Proliferation[MESH] |Cell Survival[MESH] |Cytoskeleton/physiology[MESH] |Embryonic Development[MESH] |Humans[MESH] |Ion Channel Gating[MESH] |Ischemia/metabolism[MESH] |Magnesium/metabolism[MESH] |Neoplasms/metabolism/pathology[MESH] |Neurodegenerative Diseases/metabolism/pathology[MESH] |Protein Serine-Threonine Kinases/*metabolism[MESH]Function and regulation of the channel-kinase TRPM7 in health and dise(epmc).pdf DeepDyve Pubget Overpricing