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10.1016/j.stemcr.2014.05.013 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2014.05.013 25068119!4110791!25068119     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cell+Reports 2014 ; 3 (1): 24-33 Nephropedia Template TP {{tp|p=25068119|t=2014. Wilms tumor blastemal stem cells dedifferentiate to propagate the tumor bulk |pdf=|usr=}}{{25068119}} gab.com Text Wilms tumor blastemal stem cells dedifferentiate to propagate the tumor bulk JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=25068119 #FOAvip An open question remains in cancer stem cell (CSC) biology whether CSCs are by definition at the top of the differentiation hierarchy of the tumor. Wilms' tumor (WT), composed of blastema and differentiated renal elements resembling the nephrogenic zone of the developing kidney, is a valuable model for studying this question because early kidney differentiation is well characterized. WT neural cell adhesion molecule 1-positive (NCAM1(+)) aldehyde dehydrogenase 1-positive (ALDH1(+)) CSCs have been recently isolated and shown to harbor early renal progenitor traits. Herein, by generating pure blastema WT xenografts, composed solely of cells expressing the renal developmental markers SIX2 and NCAM1, we surprisingly show that sorted ALDH1(+) WT CSCs do not correspond to earliest renal stem cells. Rather, gene expression and proteomic comparative analyses disclose a cell type skewed more toward epithelial differentiation than the bulk of the blastema. Thus, WT CSCs are likely to dedifferentiate to propagate WT blastema. Twit Text FOAVip Wilms tumor blastemal stem cells dedifferentiate to propagate the tumor bulk ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=25068119 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25068119 #FOAvip English Wikipedia <ref>{{Cite pmid|25068119}}</ref> Wilms tumor blastemal stem cells dedifferentiate to propagate the tumor bulk #MMPMID25068119 Shukrun R; Pode-Shakked N; Pleniceanu O; Omer D; Vax E; Peer E; Pri-Chen S; Jacob J; Hu Q; Harari-Steinberg O; Huff V; Dekel B Stem Cell Reports 2014[Jul]; 3 (1): 24-33 PMID25068119show ga An open question remains in cancer stem cell (CSC) biology whether CSCs are by definition at the top of the differentiation hierarchy of the tumor. Wilms' tumor (WT), composed of blastema and differentiated renal elements resembling the nephrogenic zone of the developing kidney, is a valuable model for studying this question because early kidney differentiation is well characterized. WT neural cell adhesion molecule 1-positive (NCAM1(+)) aldehyde dehydrogenase 1-positive (ALDH1(+)) CSCs have been recently isolated and shown to harbor early renal progenitor traits. Herein, by generating pure blastema WT xenografts, composed solely of cells expressing the renal developmental markers SIX2 and NCAM1, we surprisingly show that sorted ALDH1(+) WT CSCs do not correspond to earliest renal stem cells. Rather, gene expression and proteomic comparative analyses disclose a cell type skewed more toward epithelial differentiation than the bulk of the blastema. Thus, WT CSCs are likely to dedifferentiate to propagate WT blastema. |Aldehyde Dehydrogenase 1 Family[MESH] |Animals[MESH] |CD56 Antigen/metabolism[MESH] |Cell Differentiation/genetics/physiology[MESH] |Female[MESH] |Humans[MESH] |Isoenzymes/metabolism[MESH] |Kidney Neoplasms/metabolism/pathology[MESH] |Mice[MESH] |Mice, SCID[MESH] |Models, Biological[MESH] |Neoplastic Stem Cells/metabolism/*pathology[MESH] |Retinal Dehydrogenase/metabolism[MESH]Wilms tumor blastemal stem cells dedifferentiate to propagate the tum(epmc).pdf DeepDyve Pubget Overpricing