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10.4161/onci.28499

http://scihub22266oqcxt.onion/10.4161/onci.28499
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25050217!4063144!25050217
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suck abstract from ncbi

pmid25050217      Oncoimmunology 2014 ; 3 (?): e28499
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  • Radiation and anti-PD-L1 antibody combinatorial therapy induces T cell-mediated depletion of myeloid-derived suppressor cells and tumor regression #MMPMID25050217
  • Deng L; Liang H; Burnette B; Weicheslbaum RR; Fu YX
  • Oncoimmunology 2014[]; 3 (?): e28499 PMID25050217show ga
  • Tumor relapse after radiotherapy may be due to the upregulation of programmed cell death ligand 1 (PD-L1). We demonstrated that anti-PD-L1 antibody synergizes with radiation to control local and distal tumors. CD8(+)T cells mediated antitumor effects of the combination therapy by the reduction of myeloid-derived suppressor cells (MDSCs) via tumor-necrosis factor (TNF)-mediated signaling. Our study provides insight into immune- and radiation-based combinational therapies.
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