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10.1208/s12248-014-9640-5 http://scihub22266oqcxt.onion/10.1208/s12248-014-9640-5 25004823SimulationofMonoclonalAntibodyPharmacokineticsinHumansUsingaMinimalPhysiologicallyBasedModel.!4147043!25004823     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       AAPS+J 2014 ; 16 (5): 1097-109 Nephropedia Template TP {{tp|p=25004823|t=2014. Simulation of monoclonal antibody pharmacokinetics in humans using a minimal physiologically based model |pdf=|usr=}}{{25004823}} gab.com Text Simulation of monoclonal antibody pharmacokinetics in humans using a minimal physiologically based model JO: AAPS J http://www.kidney.de/pget.php?&tw=1&pmid=25004823 #FOAvip Compared to small chemical molecules, monoclonal antibodies and Fc-containing derivatives (mAbs) have unique pharmacokinetic behaviour characterised by relatively poor cellular permeability, minimal renal filtration, binding to FcRn, target-mediated drug disposition, and disposition via lymph. A minimal physiologically based pharmacokinetic (PBPK) model to describe the pharmacokinetics of mAbs in humans was developed. Within the model, the body is divided into three physiological compartments; plasma, a single tissue compartment and lymph. The tissue compartment is further sub-divided into vascular, endothelial and interstitial spaces. The model simultaneously describes the levels of endogenous IgG and exogenous mAbs in each compartment and sub-compartment and, in particular, considers the competition of these two species for FcRn binding in the endothelial space. A Monte-Carlo sampling approach is used to simulate the concentrations of endogenous IgG and mAb in a human population. Existing targeted-mediated drug disposition (TMDD) models are coupled with the minimal PBPK model to provide a general platform for simulating the pharmacokinetics of therapeutic antibodies using primarily pre-clinical data inputs. The feasibility of utilising pre-clinical data to parameterise the model and to simulate the pharmacokinetics of adalimumab and an anti-ALK1 antibody (PF-03446962) in a population of individuals was investigated and results were compared to published clinical data. Twit Text FOAVip Simulation of monoclonal antibody pharmacokinetics in humans using a minimal physiologically based model ????AAPS J http://www.kidney.de/pget.php?&tw=1&pmid=25004823 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25004823 #FOAvip English Wikipedia <ref>{{Cite pmid|25004823}}</ref> Simulation of monoclonal antibody pharmacokinetics in humans using a minimal physiologically based model #MMPMID25004823 Li L; Gardner I; Dostalek M; Jamei M AAPS J 2014[Sep]; 16 (5): 1097-109 PMID25004823show ga Compared to small chemical molecules, monoclonal antibodies and Fc-containing derivatives (mAbs) have unique pharmacokinetic behaviour characterised by relatively poor cellular permeability, minimal renal filtration, binding to FcRn, target-mediated drug disposition, and disposition via lymph. A minimal physiologically based pharmacokinetic (PBPK) model to describe the pharmacokinetics of mAbs in humans was developed. Within the model, the body is divided into three physiological compartments; plasma, a single tissue compartment and lymph. The tissue compartment is further sub-divided into vascular, endothelial and interstitial spaces. The model simultaneously describes the levels of endogenous IgG and exogenous mAbs in each compartment and sub-compartment and, in particular, considers the competition of these two species for FcRn binding in the endothelial space. A Monte-Carlo sampling approach is used to simulate the concentrations of endogenous IgG and mAb in a human population. Existing targeted-mediated drug disposition (TMDD) models are coupled with the minimal PBPK model to provide a general platform for simulating the pharmacokinetics of therapeutic antibodies using primarily pre-clinical data inputs. The feasibility of utilising pre-clinical data to parameterise the model and to simulate the pharmacokinetics of adalimumab and an anti-ALK1 antibody (PF-03446962) in a population of individuals was investigated and results were compared to published clinical data. |*Computer Simulation[MESH] |*Models, Biological[MESH] |Adalimumab[MESH] |Antibodies, Monoclonal, Humanized/administration & dosage/blood/*pharmacokinetics[MESH] |Antibodies, Monoclonal/administration & dosage/blood/*pharmacokinetics[MESH] |Drug Administration Routes[MESH] |Drug Dosage Calculations[MESH] |Feasibility Studies[MESH] |Half-Life[MESH] |Histocompatibility Antigens Class I/metabolism[MESH] |Humans[MESH] |Immunoglobulin G/metabolism[MESH] |Lymph/metabolism[MESH] |Metabolic Clearance Rate[MESH] |Monte Carlo Method[MESH] |Permeability[MESH] |Protein Binding[MESH]Simulation of monoclonal antibody pharmacokinetics in humans using a m(epmc).pdf DeepDyve Pubget Overpricing