
| 10.1016/j.antiviral.2014.06.013
http://scihub22266oqcxt.onion/10.1016/j.antiviral.2014.06.013
 24995382!7113789!24995382
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Antiviral+Res 2014 ; 109 (�): 97-109 Nephropedia Template TP
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Accessory proteins of SARS-CoV and other coronaviruses #MMPMID24995382Liu DX; Fung TS; Chong KK; Shukla A; Hilgenfeld RAntiviral Res 2014[Sep]; 109 (�): 97-109 PMID24995382show ga
The huge RNA genome of SARS coronavirus comprises a number of open reading frames that code for a total of eight accessory proteins. Although none of these are essential for virus replication, some appear to have a role in virus pathogenesis. Notably, some SARS-CoV accessory proteins have been shown to modulate the interferon signaling pathways and the production of pro-inflammatory cytokines. The structural information on these proteins is also limited, with only two (p7a and p9b) having their structures determined by X-ray crystallography. This review makes an attempt to summarize the published knowledge on SARS-CoV accessory proteins, with an emphasis on their involvement in virus-host interaction. The accessory proteins of other coronaviruses are also briefly discussed. This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses" (see Introduction by Hilgenfeld and Peiris (2013)).|Animals[MESH]|Coronavirus Infections/*virology[MESH]|Coronavirus/classification/genetics/metabolism[MESH]|Humans[MESH]|Open Reading Frames[MESH]|Severe acute respiratory syndrome-related coronavirus/genetics/*metabolism[MESH]
  
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