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10.1111/crj.12177 http://scihub22266oqcxt.onion/10.1111/crj.12177 24992168!7162323!24992168     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Respir+J 2016 ; 10 (1): 22-31 Nephropedia Template TP {{tp|p=24992168|t=2016. Critical role of RIG-I-like receptors in inflammation in chronic obstructive pulmonary disease |pdf=|usr=}}{{24992168}} gab.com Text Critical role of RIG-I-like receptors in inflammation in chronic obstructive pulmonary disease JO: Clin Respir J http://www.kidney.de/pget.php?&tw=1&pmid=24992168 #FOAvip INTRODUCTION: Viral infection is a significant cause of chronic obstructive pulmonary disease (COPD) and acute exacerbation of COPD. Retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation associated gene 5 (MDA-5), are important pattern recognition receptors for viral elimination. OBJECTIVE: The study aims to investigate the role of RIG-I and MDA-5 in COPD pathogenesis. METHODS: We examined the expression of RIG-I and MDA-5 by immunohistochemistry, real-time PCR and Western blots in COPD patients and control subjects. RESULTS: Our results showed that MDA-5 expression was upregulated in lung tissues and peripheral blood mononuclear cells of COPD patients and there was a negative correlation between MDA-5 mRNA levels and forced expiratory volume in 1 s %pred. COPD patients had higher interleukin (IL)-1 and IL-8 mRNA expression levels, and these inflammatory cytokines positively correlate with MDA-5 levels. However, there was no difference in the expression of RIG-I between COPD patients and control subjects. CONCLUSION: Our results suggested that MDA-5, but not RIG-I, may play a critical role in airway inflammation in COPD. Twit Text FOAVip Critical role of RIG-I-like receptors in inflammation in chronic obstructive pulmonary disease ????Clin Respir J http://www.kidney.de/pget.php?&tw=1&pmid=24992168 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24992168 #FOAvip English Wikipedia <ref>{{Cite pmid|24992168}}</ref> Critical role of RIG-I-like receptors in inflammation in chronic obstructive pulmonary disease #MMPMID24992168 Zhang Q; Wan H; Huang S; Zhang Y; Wang Y; Guo X; He P; Zhou M Clin Respir J 2016[Jan]; 10 (1): 22-31 PMID24992168show ga INTRODUCTION: Viral infection is a significant cause of chronic obstructive pulmonary disease (COPD) and acute exacerbation of COPD. Retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation associated gene 5 (MDA-5), are important pattern recognition receptors for viral elimination. OBJECTIVE: The study aims to investigate the role of RIG-I and MDA-5 in COPD pathogenesis. METHODS: We examined the expression of RIG-I and MDA-5 by immunohistochemistry, real-time PCR and Western blots in COPD patients and control subjects. RESULTS: Our results showed that MDA-5 expression was upregulated in lung tissues and peripheral blood mononuclear cells of COPD patients and there was a negative correlation between MDA-5 mRNA levels and forced expiratory volume in 1 s %pred. COPD patients had higher interleukin (IL)-1 and IL-8 mRNA expression levels, and these inflammatory cytokines positively correlate with MDA-5 levels. However, there was no difference in the expression of RIG-I between COPD patients and control subjects. CONCLUSION: Our results suggested that MDA-5, but not RIG-I, may play a critical role in airway inflammation in COPD. |Aged[MESH] |DEAD Box Protein 58[MESH] |DEAD-box RNA Helicases/*biosynthesis/genetics/metabolism[MESH] |Female[MESH] |Forced Expiratory Volume/physiology[MESH] |Humans[MESH] |Inflammation/genetics/*metabolism[MESH] |Interferon-Induced Helicase, IFIH1[MESH] |Interleukin-1/biosynthesis/genetics[MESH] |Interleukin-8/biosynthesis/genetics[MESH] |Male[MESH] |Middle Aged[MESH] |Pulmonary Disease, Chronic Obstructive/genetics/*metabolism/physiopathology[MESH] |Receptors, Immunologic[MESH]Critical role of RIG-I-like receptors in inflammation in chronic obstr(epmc).pdf DeepDyve Pubget Overpricing